Cell–extracellular matrix (ECM) adhesion is a fundamental requirement for multicellular existence due to roles in positioning, proliferation and differentiation. Phosphorylation plays a major role in adhesion signalling; however, a full understanding of the phosphorylation events that occur at sites of ad...
Although death is inevitable, individuals have long sought to alter the course of the ageing process. Indeed, ageing has proved to be modifiable; by intervening in biological systems, such as nutrient sensing, cellular senescence, the systemic environment and the gut microbiome, phenotypes of ageing...
process for the production enzymhemmender substances through phosphorylation of glycosides provokesROSENBERG ERNST THOMASLINDEROT TORSTEN OVE ENOKHOEGBERG KNUT BERTILFERNOE OVE BIRGERFEX HANS JAKOB
Metabolic reprogramming is a hallmark of tumors. Although the Warburg effect represents the preference of tumor cells for anaerobic glycolysis, mitochondrial oxidative phosphorylation (OXPHOS) is also indispensable for maintaining the stemness of some cancer stem cells (CSCs). CSCs derived from GBM, pan...
Various diseases, such as inflammation and cancer, can develop when signaling through the Akt/mTOR pathway is inefficient [16, 17]. Natural plants that can attenuate the liver fibrosis by regulating the phosphorylation of components in the Akt/mTOR pathway have attracted attention [18]. Actually,...
Western-blots were performed as described previously (Li, Li, et al., 2014), to determine changes in protein content and/or phosphorylation. The following antibodies were used: anti-cleaved-caspase3, anti- Bcl2, anti-Bax, anti-phospho-JNK, anti-JNK, anti-phospho-p38, anti-p38, anti-ERK...
The discovery of DNA and the subsequent discovery of DNA replication revealed that nucleotide incorporation is preceded by nucleotide phosphorylation (Fig.1). Fig. 1 TK1 timeline: a summary of major discoveries regarding the functions, regulation, and characterization of TK1 ...
The PTS couples solute transport to its phosphorylation at the expense of phosphoenolpyruvate (PEP) and it also plays a central role in the regulation of a number of cell processes in some bacteria [3–6]. This system consists of general cytoplasmic energy-coupling proteins, enzyme I (EI) ...
thought to primarily act by antagonizing PI3-kinase signalling. Here we demonstrate that PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (DVL), another ciliogenesis regulator. DVL is a central component of WNT signalling that ...
before detailing the vast diversity of cytoplasmic inheritance systems across Eukaryota. We then describe the evolution of genomic organisation across lineages, how this process has been shaped by interactions with the nuclear genome and population genetics dynamics. Finally, we discuss how both nuclear ...