Endogenous RNA transcription characterizes double-stranded RNA (dsRNA) viruses in the Reoviridae, a family that is exemplified by its simple, single-shelled member cytoplasmic polyhedrosis virus (CPV). Because of the lack of in situ structures of the intermediate stages of RNA-dependent RNA ...
19,20but not in humans32. Heinz et al.35showed that transcription disrupts TAD borders by displacing cohesin and CTCF during influenza A virus infection, while others found that transcription drives the formation of domain borders inCaulobactercells36. These opposing findings suggest...
Mitochondrial division is not an autonomous event but involves multiple organelles, including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the constriction of mitochondrial membranes, the role of lysosomes in mitochondrial division
It should be noted that cell fusions may also give rise to polyploidy [36] or perhaps the parasexual events represent an intermediate step in the process of reversing tumour cell polyploidy, however their importance and sequence in this process is unclear. Similarly, although the means and cons...
Exclusively, high coverage data of the Alpha (97 samples), Delta (250 samples) and Omicron (76 samples) variants were used. We used the phylogenetic pipeline and approach described by Perera et al. [21]. The pipeline consisted of the following steps: (i) data extraction; (ii) Multiple ...
of a series of complicated and coordinated events. Implantation of the human embryo requires three sequential steps: apposition, adhesion and invasion (Fig.1). During the secretory phase of the menstrual cycle, the endometrial stromal cells start to undergo decidualization under the drive of ...
(SCENIC) pipeline18and calculated the regulon activity score (RAS) for each spatial spot. We found the spatial domains based on RAS were consistent with the spatial gene expression clusters (Supplementary Fig.5a–c), indicating that the activity of transcription factors (TFs) regulatory network ...
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all patients experienced favorable clinical o
at room temperature; the samples were subsequently loaded onto columns for the other steps of the purification procedure. After washing with 20 bed volumes of PBS, for each mL of Glutathione-Sepharose bed volume were mixed 50 μL of thrombin solution (1U/μL) and 950 μL of PBS. The susp...
The function of the nuclear body is unknown. The periphery of the nuclear body has been shown to be the preferred site where the early steps of transcription and replication of three DNA virus families take place (20). In APL cells, the nuclear bodies were dispersed into a microspeckle ...