The resulting enolate intermediates subsequently react with electrophiles (aldehydes, imines, α,β-unsaturated nitro, alkyl halides, acyl cyanides) to form a quaternary center. Tethering of the electrophile and nucleophile components provides cyclic α,α-disubstituted α-amino acid derivatives....
α-aminonitrilesCMK-5solid sulfonic acidStreckerthree componentsThe one﹑ot threeヽomponent synthesis of a variety of α゛minonitriles has been studied using a catalytic amount of a sulfonic acid‐functionalized ordered nanoporous carbon catalyst, CMKO3H, at room temperature under solvent‐free ...
ACID-DERIVATIVESMICHAEL ADDITIONFINE CHEMICALSBASE CATALYSTSSynthetic phosphate Na2CaP2O7 has been utilized as an efficient catalyst for the three components coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphite to produce a-amino phosphonates. The reaction was carried out ...
The Strecker amino acid synthesis via a three-component reaction of amines, aldehydes, and cyanides has been recognized as one of the most important landmarks in the field of modern organic chemistry. The key to this synthetic process is the reaction components. The Strecker reaction is classifi...
wt. of 300-2000. Heat- or light-cured coating material with at least 3 components, comprising (I) a binder component (A) containing oligomeric or polymeric resin(s) with functional groups which react with isocyanate, (II) a crosslinker component (B) containing polyisocyanate(s) and (III) ...
Several of the studied reactions provide β-amino carbonyl compounds (Mannich products) in excellent enantio-, diastereo-, regio-, and chemoselectivities. The scope of each of the three components and the influence of the catalyst structure on the reaction are described. Reaction conditions have ...
These protein components stem from independently encoded and proteolytically processed precursor proteins. Only the structure of the protein component responsible for the inhibitory activity has been established so far. We now present the complete amino acid sequence of the precursor of the second protein...
A new methodology for the synthesis of β-amino acids Naturally occurring β-amino acids are compounds with an interesting pharmacological profile.1They are also found as components in a wide variety of bi... MP Sibi - 《Journal of the Chemical Society Perkin Transactions》 被引量: 0发表: 19...
The root of the universal tree of life inferred from anciently duplicated genes encoding components of the protein-targeting machinery. J. Mol. Evol. 47, 508–516 (1998). Article CAS PubMed Google Scholar Cao, T. B. & Saier, M. H. Jr. The general protein secretory pathway: ...
On the other hand, a series of non-deleterious mutations might change the function of the duplicate gene copy [20]. Natural selection can prevent the loss of redundant genes [21] if those genes code for components of multidomain proteins, because mutant alleles disrupt such proteins. A ...