These cells were generated from the human THP1-Dual™ monocytic cell line through a biallelic knockout (KO) of the TLR4 gene. They also feature two inducible reporter genes, allowing the concomitant study of the NF-κB and IRF pathways, by monitoring the respective SEAP (secreted embryonic ...
Dual Reporter THP-1 Cells with stable overexpression of TLR7 ± a knockout of TLR8. These cells allow the simultaneous study of NF-kB and IRF pathways.
THP1-Dual cells were derived from the human THP-1 monocyte cell line by stable integration of two inducible reporter constructs. THP1-Dual cells allow the simultaneous study of the NF-kB pathway, by monitoring the activity of SEAP, and the IRF pathway, b
THP1-Difluo™ hLC3 reporter cells are designed to monitor the autophagic flux by means of a fluorescent-labeled LC3B protein. These cells, derived from the THP-1 human monocytic cell line, express the RFP::GFP::LC3 fusion protein in which the human LC3B (microtubule-associated protein 1 ...
• THP1-defNLRP3 cells –Knockdown (KD) of the NLRP3 geneThese cell lines exhibit a similar phenotype but have dramatically different genotypes. They share the common phenotype of abrogation of mature IL-1β secretion. However, THP1- defNLRP3 cells exhibit a knockdown of NLRP3 gene ...