Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep. 2014;3:481. PubMed PubMed Central Google Scholar Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z, Goodman SB. Inflammation, fracture and...
Besides the canonical immune checkpoints PD-1 and CTLA-4, alternative negative regulatory checkpoints have been found and are focused on by cancer biologists, clinical oncologists, and industry. Biology and therapeutic potential of the immunoglobulin (Ig) superfamily (IgSF) members, including LAG-3,...
4]. But, functional genomic studies have identified vulnerabilities with other genes causing sustained synthetic lethal interactions [5,6,7]. Synthetic lethality occurs when the combination of deficiencies in the expression or function of two genes leads to cell death, whereas a deficiency in only o...
Wang, S. Sims-Lucas, E. Cherok, K. Rothermund, M.F. Branca, et al. Mitochondrial structure, function and dynamics are temporally controlled by c-Myc PLoS One, 7 (5) (2012), Article e37699 CrossrefView in ScopusGoogle Scholar [136] G. Varano, S. Raffel, M. Sormani, F. Zanardi,...
Results of clinical trials aimed at blocking the IL-23/IL-17 axis in patients with AS support involvement of this pathway in the pathogenesis of axSpA [2]. As such, IL-17 has emerged as a novel therapeutic target in AS. Secukinumab is the only IL-17A inhibitor currently indicated for the...
Hamner JB, Sims TL, Cutshaw A, Dickson PV, Rosati S, McGee M., et al.: The efficacy of combination therapy using adeno-associated virus-interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. J Pediatr Surg 2008, 43:177-183....
Fig. 4: LBH DNA methylation status and prognostic value in cancers. A CpG methylation level of LBH in normal and primary tumor tissue among cancer types in TCGA. Box plots were generated using SMART webtool. Wilcoxon rank sum test; P-values: *p ≤ 0.05; **p ≤ 0.01; ***p ...
Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical management is highly challenging due to their heterogeneity and insensitivity to current treatments. Although there have been advances in understanding specific genomic alte
Quentmeier, H.; Drexler, H.G.; Fleckenstein, D.; Zaborski, M.; Armstrong, A.; Sims, J.E.; Lyman, S.D. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia 2001, 15, 1286–1292. [Google Scholar] [CrossRef] [PubMed] The ...
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