Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep. 2014;3:481. PubMed PubMed Central Google Scholar Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z, Goodman SB. Inflammation, fracture and...
Download: Download high-res image (655KB) Download: Download full-size image Fig. 4. Novel therapeutic targets in Richter transformation. RT in the era of new targeted therapies Over the course of the last decade, there has been a profound transformation in the therapeutic milieu for patients ...
1–4), we started this analysis in COAD, STAD, LIHC, PAAD, and ESCA. We first queried individual cancer datasets from TCGA to identify LBH co-expressed genes using the R2 platform with Bonferroni correction and a p-value < 0.01. We then overlapped these gene clusters from at least ...
Chi V, Pennington M, Norton R, Tarcha E, Londono L, Sims-Fahey B, Upadhyay S, Lakey J, Iadonato S, Wulff H, et al. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012;59:529–46. Article CAS Google Scholar Wulff H, Calabresi...
Hamner JB, Sims TL, Cutshaw A, Dickson PV, Rosati S, McGee M., et al.: The efficacy of combination therapy using adeno-associated virus-interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. J Pediatr Surg 2008, 43:177-183....
[81]. SMARCA2/4 and PB1(2-5) are canonical BRDs, whereas the first and sixth BRD of PBRM1 have either an occluded binding site or lack the conserved asparagine. The PB1(2-4) BRDs additionally have a specific tyrosine in the ZA loop that acts as a lid at the entrance of the ...
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the
Microtubule-associated protein tau (MAPT) is a gene responsible for encoding tau protein, which is tightly implicated in keeping the function of microtubules and axonal transport. Hyperphosphorylated tau protein participates in the formation of neurofibrillary tangles (NFTs), which characterize many neurod...
(BM)-MSCs into osteosarcoma in vivo and when combined with loss of the Ink4a/Arf locus, the process was substantially accelerated.122The authors further showed that these osteosarcoma cells consisted of two subpopulations with one showing altered tri-lineage differentiation potential and resistance to...
Long-term complications and associated conditions of type 1 Gaucher Disease (GD) can include splenectomy, bone complications, pulmonary hypertension, Parkinson disease and malignancies. Enzyme replacement therapy (ERT) reverses cytopenia and reduces orga