Drug therapies of brain cancer have been particularly inefficient, due to the blood鈥揵rain barrier and the non-specificity of the potentially toxic drugs. The nanoparticle has emerged as a potential vector for brain delivery, able to overcome the problems of current strategies. Moreover, multi-...
Israeli researchers at the Hebrew University Hadassah Medical School made a ground breaking discovery of a cancer-driving protein.
Brain cancer is the second-leading cause of death in children in the developed world. For the children who survive, standard treatments have long-term impacts on their development and quality of life, particularly in small children and infants. Research out of Emory University and QIMR Berghofer ...
There is increasing evidence that many types of cancer contain their own stem cells: cancer stem cells (CSC), which are characterized by their self-renewing capacity and differentiation ability. The investigation of solid tumour stem cells has gained momentum particularly in the area of brain ...
Glioblastoma multiforme (GBM) is one of the most common and aggressive types of brain cancer, accounting for “47.7% of all cases” of this type of cancer. “Glioblastoma has an incidence of 3.21 per 100,000 population,” according to the American Association of Neurological Surgeons (AANS)....
brain cancerBrain cancer therapy has become a huge challenge compared with peripheral cancers because of the physiological characteristic of the brain-blood barrier (BBB), which prevents most therapeutical drugs from reaching the cancer tissues. For years, efforts have been made in nanotechnology, ...
the study covered almost 1,500 patients from Penn Medicine. It was the first large review of data across several cancer types including lung, brain, head and neck, gastrointestinal and gynecologic cancers, but none of the patients had metastatic cancer, in which a tumor has spread to other pa...
When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targetingbreast cancer cellsin the brain aren't effective, because the...
Fig. 1: Mechanisms of NK cell deactivation in the brain tumor microenvironment. Mechanisms of NK cell deactivation by cancer cells include the expression of MHC-I, PD-1, CD155, and CD73 expression on cancer cells that can inhibit NK cells. Cytokine and chemokine release, such as IL-6, IL...
Early prediction of response is also of benefit from a research point of view, she added. "When researchers are looking for new agents and treatment methods, they really want a test that is reliable and is a good way to measure lesion response, so this type of imaging is a boon in that...