6) fluorouracil/therapentic use 氟尿嘧啶治疗应用补充资料:速尿 分子式:C12H11ClN2O5S分子量:330.750CAS号:54-31-9性质:白色或类白色结晶性粉末。熔点206℃。溶于丙酮,甲醇,二甲基甲酰胺,略溶于乙醇,不溶于水。无臭,几乎无味。制备方法:由2,4-二氯苯甲酸(见12740)经氯磺化,氨化,酸化得到2,4-二氯-5-氨...
Similar to megalin, TRP channels are present in the membrane of kidney epithelial cells and of inner ear sensory cells, thus may also be involved in oto- and nephrotoxic effects of AAGs. Moreover, AAGs uptake may also be stimulated by loop diuretics, like bumetanide and furosemide. These ...
Bumetanide is forty times more potent than furosemide and is a loop diuretic mainly acting in the ascending limb of the loop of Henle. A clinical trial conducted found a decrease in the Childhood Autism Rating Scale (CARS) score, showing improvement in Autism Spectrum Disorder symptoms, such as...
Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induced by pharmaceutical compounds is a promising
Moreover, AAGs uptake may also be stimulated by loop diuretics, like bumetanide and furosemide. These Dabrowski et al. Molecular Medicine (2018) 24:25 Page 9 of 15 drugs, which hyperpolarize the cell membrane, were shown to increase the influx of a cationic AAG (GTTR) through NSCCs, ...
Despite considerable therapeutic advances, heart failure remains a medical and socioeconomic problem. Thus, there is a compelling need for new drugs that could improve clinical outcomes. In recent years, new potential therapeutic targets that are involved in the pathogenesis of heart failure have been...
(type 2b reasoning). On the basis the therapy chosen, therapy scripts can be developed which can be used in new situations. In an uncertain diagnosis the therapy choice can be used as diagnostic tool,e.g. seeing whether prednisone for presumed polymyalgia rheumatica or furosemide for presumed ...
The past decade has witnessed major strides in the prevention of CHD through modification of its causes. The most dramatic advance has been the demonstration in a “mega International” study of 17,800 men and women with normal cholesterol levels that found rosuvastatin (statin use) cuts deaths ...
Saluretics (furosemide, spironolactone or amiloride, among others) Can increase excretion of potassium Pharmacodynamic interactions Cytochrome 450 inhibitors (ketoconazole, itraconazole, HIV protease inhibitors, grapefruit juice) Can increase exposure to BUD several times. Since there is no data to support...
Finnerty, F.A.: Advantages and disadvantages of furosemide in the edematous states of pregnancy. American Journal of Obstetrics and Gynecology 105: 1022–1027(1969). PubMed Google Scholar Finnerty, F.A.: Treatment of acute hypertension in pregnancy. Obstetrics Gynecology Digest 12: 30–37 (1970...