Therapeutic ranges and laboratory monitoring of heparin using the APTTMaeder, Ellena M.Giannoutsos, JohnVanniasinkam, ThiruFavaloro, Emmanuel J.Australian Journal of Medical Science
The activated partial thromboplastin time (aPTT) test has been used to monitor UFH therapy for decades in Korea, but its results can be affected by numerous variables. We established an aPTT heparin therapeutic range (HTR) corresponding to therapeutic anti-Xa levels for continuous intravenous UFH ...
The commonly used ratio of 1.5 to 2.5 times the normal control value is appropriate for some reagents, but for the other reagents a higher or lower range is appropriate. A suitable aPTT reagent for heparin control should be sensitive both to a threshold effect of heparin and to increasing ...
A TT within the reference range excludes a (remaining) dabigatran-associated anticoagulant effect [see (a) in the section “Clinical question: Which test should be used to rule out the presence of dabigatran anticoagulation”]. In this case, the administration of idarucizumab is not required. ...
241 RISK OF SUPRATHERAPEUTIC APTT IN THE ABSENCE OF AN INITIAL UNFRACTIONATED HEPARIN BOLUS F Bonenfant, B Cossette, V Nault, M Turgeon, M Paulin, D Echenberg, P Charron, M Lépine, T Fayad, P Farand Sherbrooke, Québec BACKGROUND: Unfractionated heparin (UFH) is an anticoag- ulant ...
and escalating the secretion of acute-phase proteins in the severe cases of COVID-19.69SARS-CoV-2 infection induces a wide range of immune cells including macrophages, neutrophils, DCs and lymphocytes to secrete excessive amounts of IL-6.70,71Excessive IL-6 promotes the differentiation of Th17 ce...
(CL20040APHP; Cedarlane, Burlington, Canada)71. Samples were analyzed at different dilutions (1/20, 1/40 and 1/100). FIX activity was measured by activated partial thromboplastin time (aPTT)26. Protein concentration in diluted supernatant was calculated using a standard curve containing known ...
range from 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material consisting essentially of the SCP and a cation exchange resin where the weight ratio of SCP to cation exchange resin is in a range from 0.1:100 to 100:0 to produce a ...
The antiviral activity of GS-5734 was selective, as demonstrated by low cytotoxicity in a wide range of human primary cells and cell lines (Extended Data Table 1). Isolation and expression of EBOV RdRp has been elusive, but computational analysis of the catalytic palm subdomain demonstrated ...
The recommendation was to adjust the dose of unfractionated heparin in order to prolong the activated partial thromboplastin time (aPTT) to a range that corresponds to a heparin level of 0.2 to 0.4 U/mL by protamine titration or 0.3 to 0.6 or 0.7 U/mL by heparin anti-factor Xa analysis....