COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONSThe present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/ or restore protein homeostasis. The disclosure provides a method of modulating a ...
A new method of desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, po... Takáts,Zoltán,Wiseman,... - 《Science》 被引量: 2626发表: 2004年 Electrostatic Axially Harmonic Orbital Trapping:鈥A High-Performance ...
This detailed annotation of current FDA-approved drugs includes peptides targeting ~670 human genome-derived proteins mapped to therapeutic indications. Article CAS PubMed Google Scholar Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schioth, H. B. & Gloriam, D. E. Trends in GPCR...
Venoms are the secretions produced by animals, generally for the purpose of self-defense or catching a prey. Biochemically venoms are mainly composed of proteins, lipids, carbohydrates, ions, etc., and classified into three major classes, viz. neurotoxic, hemotoxic and cytotoxic based upon their ...
However, for integral membrane proteins, special consideration must be given to the need to both extract them from the membrane and subsequently mask their hydrophobic surfaces with amphiphilic agents. This has classically been achieved using detergent compounds, which must be exhaustively screened to ...
bacteriophages by the fusion of a gene encoding a coat protein is the most widely used.57Screening of an antibody library, such as an immune or synthetic library, has been performed against different types of antigens, purified proteins, peptides,47,48,58whole cells50,59and proteoliposomes.52...
action [54,55]. Remarkably, curcumin acts through targeting several signaling pathways, making the proliferation of cervical cancer cells revert to normal. It also mediates important alterations in tumor-associated proteins correlated with cell metabolism, cell cycle, and carcinogenicity in HeLa cells [...
With an increasing number of therapeutic proteins moving into preclinical and clinical development, pharmacokinetic factors play an important role in the development of these macromolecules. It is also important that the pharmacokinetic evaluation of these compounds be done as accurately as possible. For ...
A new concept for macromolecular therapeutics in cancer-chemotherapy — mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res. 46, 6387–6392 (1986). CAS PubMed Google Scholar Salazar, M. D. & Ratnam, M. The folate receptor: what does it promise in ...
Self-assembly of cricoid proteins induced by “soft nanoparticles”: an approach to design multienzyme-cooperative antioxidative systems. ACS Nano 9, 5461–5469 (2015). Article CAS Google Scholar Huang, X., Yin, Y. & Liu, J. Design of artificial selenoenzymes based on macromolecular scaffolds...