Once a rarely used subset of medical treatments, protein therapeutics have increased dramatically in number and frequency of use since the introduction of the first recombinant protein therapeutic — human insulin — 25 years ago. Protein therapeutics already have a significant role in almost every fie...
Recombinant ProteinsOnce a rarely used subset of medical treatments, protein therapeutics have increased dramatically in number and frequency of use since the introduction of the first recombinant protein therapeutic--human insulin--25 years ago. Protein therapeutics already have a significant...
A. Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases. Trends in ... T Nakamura,SA Lipton - 《Trends in Pharmacological Sciences》 被引量: 51发表: 2016年 Structure-Guided deimmunization of therapeutic proteins 2008. Protein therapeutics: a summary and pharmacological ...
The first one was represented by the sequences separated from the therapeutic proteins (n= 84) able to form APR. A control set (CS) consisted of peptides that were chosen based on 22 tregitope sequences. Classification model and four classes (A, B, C, D) of sequences were finally...
Structural insight of the protein–protein interaction (PPI) interface can provide knowledge about the kinetics, thermodynamics and molecular functions of the complex while elucidating its role in diseases and further enabling it as a potential therapeutic target. However, owing to experimental lag in ...
Exploring the binding potential of carbon nanotubes and fullerene towards major drug targets of multidrug resistant bacterial pathogens and their utility as novel therapeutic agents SinoshSkariyachan,ShruthiGarka, inFullerens, Graphenes and Nanotubes, 2018 ...
the Ro5-1 would classify 4 out of the 10 PPI drugs as drug-like, 40% higher than the conventional Lipinski’s rules. Taking this into account, it is clear that poor chemical-biological candidates can have promising therapeutic properties and that such compounds should not be dismissed due to...
Classification of anticancer drugs-a new system based on therapeutic targets E Espinosa,P Zamora,J Feliu,... - 《Cancer Treatment Reviews》 被引量: 0发表: 2003年 Classification of Anticancer Drugs Based on Therapeutic Targets Espinosa E, Raposo CG (2010) Classification of Anticancer Drugs Based ...
Identification of new drug classification terms in textual resources Knowledge about biological effects of small molecules helps in the understanding of biological processes and supports the development of new therapeutic ag... Corinna Koláik,M Hofmann-Apitius,M Zimmermann,... - 《Bioinformatics》 被...
There are different criteria for therapeutic drug design. One is selectivity, as it seems appropriate that drugs act selectively through specific receptors. Another is the concept of receptor polypharmacology in which a drug exerts a combination of positive effects by binding to different receptors [...