Severe hypercholesterolemia in persons refractory to diet and maximum drug therapy who are homozygous for familial hypercholesterolemia (LDL apheresis, also known as heparin-induced extracorporeal LDL precipitation (HELP) or dextra sulfate adsorption) with LDL levels greater than 500 mg/dL, or persons he...
In recent years, computational-assisted drug discovery (CADD) has emerged as a powerful approach to expedite the identification and optimization of novel therapeutic compounds. CADD empowers researchers to accurately predict the interactions between small molecules and biological targets by utilizing computat...
The Clinic Arlesheim is a Swiss anthroposophic hospital offering IO treatments for cancer patients, including drug therapies, of which MT is the most used complementary anti-cancer treatment. In addition, complementary drug and/or non-drug therapies are offered that focus on the physical and psycho...
The anti-epileptic drug carbamazepine (Tegretol) is the drug most frequently used for the management of TN. For patients who can not tolerate carbamazepine because of its adverse side effects (poor liver function, confusion, ataxia, drowsiness, and allergic responses), the literature indicates ...
Mechanistically, AGD1 interacts with METTL13 and USP10, mediating the ubiquitination and stability of METTL13 at the protein level. Consequently, METTL13 enhances the stability of CD44 mRNA through m6A transcriptional modification. Furthermore, liposomal-chitosan/siAGD1 nanocomplexes drug delivery ...
A. (2009). Cognitive-behavioral treatment with adult alcohol and illicit drug Users: A meta-analysis of randomized controlled trials. Journal of Studies on Alcohol and Drugs, 70, 516–527. PubMed PubMed Central Google Scholar Mandal, S. P., Arya, Y. K., & Pandey, R. (2014). ...
41 NATURE REVIEWS | DRUG DISCOVERY VOLUME 4 | APRIL 2005 | 2 8 7 REVIEWS Table 6 | Botulinum serotype B light chain (BoNT/B LC) inhibitors BoNT/B LC inhibitor chemical structure Name HH NN O NH H2N O O O Cl HN NH2 ICD-1578 BABIM In vitro activity References IC50 = 27 µM 46...
These biomarkers may aid in screening and supporting early detection of PTSD, as well as identifying drug targets that will lead to timely intervention and better outcomes for individuals suffering from PTSD [38,39,40]. Based on our research findings, we have identified VNN1, SERPINB2, and ...
Proportions of diagnoses per ICD-10 sub-chapter were evaluated to find diseases and to rank the occurrence of diagnoses in the population of indigenous people. Thereafter, the available medication provided by the indigenous health care provider Dusakawi for the treatment of the indigenous patients ...
(or immunologically neutral) therapies, which currently is the case [10]. Moreover, drug discovery programs have been designed to actively search for ICD inducer and two of such drugs, i.e., lurbinectedin and belantamab mafodotin, have received regulatory approval for use in cancer ...