Unfractionated heparin (UFH) has unstable pharmacokinetics and requires close monitoring. The activated partial thromboplastin time (aPTT) test has been used to monitor UFH therapy for decades in Korea, but its results can be affected by numerous variables. We established an aPTT heparin therapeutic ...
Therapeutic ranges and laboratory monitoring of heparin using the APTTMaeder, Ellena M.Giannoutsos, JohnVanniasinkam, ThiruFavaloro, Emmanuel J.Australian Journal of Medical Science
BACKGROUND: Protocolled treatment with unfractionated heparin (UFH) is a subject of ongoing debate. Even though international guidelines prescribe calibration of the activated partial thromboplastin time (aPTT) to 0.3 to 0.7 U/mL anti-Xa activity to establish an UFH therapeutic range, evidence for ...
S. et al. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood 119, 2401–2408 (2012). CAS PubMed Google Scholar Buller, H. R. et al. Factor XI antisense oligonucleotide for prevention of venous thrombosis. N. Engl. J. ...
241 RISK OF SUPRATHERAPEUTIC APTT IN THE ABSENCE OF AN INITIAL UNFRACTIONATED HEPARIN BOLUS F Bonenfant, B Cossette, V Nault, M Turgeon, M Paulin, D Echenberg, P Charron, M Lépine, T Fayad, P Farand Sherbrooke, Québec BACKGROUND: Unfractionated heparin (UFH) is an anticoag- ulant ...
Standard coagulation tests (PT, aPTT) are not suitable for detecting a NOAC effect but, depending on the NOAC, they may indicate the presence of an anticoagulant. The effects of anticoagulant therapy on these tests vary according to the dose and the time elapsing since ingestion. However, meani...
(APTT).7About 60% ICU patients had abnormally elevated D-dimer levels compared with a prevalence of 43% in non-severe patients.131Moreover, increased D-dimer levels were associated with adverse prognosis.132In severe COVID-19 patients, thrombotic complications are common due to the prothrombotic...
(f, qPCR;n = 2 day 9;n = 4 day 12) and protein level (g, ELISA on supernatants,n = 3 day 7;n = 4 day 9 and 12; 3 donors). Bars represent mean ± SD.hComparison of FIX antigen (ELISA) and activity (aPTT) in supernatants of KI HSPCs (mean;n =...
The ratio of virus-positive cells to total number of analysed cells was used to determine the percentage of infection for each well on the assay plates. The effect of compounds on the viral infection was assessed as percentage of inhibition of infection in comparison to control wells. The ...
(Hg, Hct, RBC, WBC, differential, and platelets), coagulation panel: aPTT, PT, INR, D-Dimer and fibrinogen, hemodynamic monitoring (Vital signs Q15 min/Hemodynamics Q30 min), vital signs (blood pressure—M, S/D, oxygen saturation & temperature), hemodynamics (PAP, PCWP, CVP, CO, PVR ...