Kruger S, Haas M, Burger PJ, Ormanns S, Modest DP, Westphalen CB, et al. Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma. J Cancer Res Clin Oncol. 2016;142:2585-91....
Advances in research on the biology of cancer revealed alterations in several key pathways underlying tumorigenesis and provided molecular targets for developing new and improved existing therapies. Syndecan-4, a transmembrane heparan sulfate proteoglycan, is a central mediator of cell adhesion, migration ...
All Special IssuesBiomedicines: 10th Anniversary4D-Transcription in Inflammation and DiseaseAdiponectin and Its Receptor Interactions in Human DiseaseAdvances in Cardiovascular Pharmacology: The Era of Targeted Therapies in CardiologyAdvances in Cardiovascular Pharmacology: The Era of Targeted Therapies in Cardiol...
Eosinophilic pustular folliculitis (EPF) or Ofuji disease is a rare dermatosis, prone to recurrence and chronicity. The peak incidence occurs in the third decade of life and its exact etiology remains unknown. Evidence suggests that the expression of adhesion molecules and the production of cytokine...
later-stage pathogenic pathways with other forms of proteinuric ckd. advances in the understanding of fibrosis regulation in prevalent diseases, such as dn, and their therapeutic implications may be used to develop therapeutic approaches to less common conditions like fabry disease. in dn intrinsic ren...
A 33 weeks' gestation, a baby with rhesus hemolytic disease (RHD), who had received intrauterine transfusions twice, developed cholestatic hepatic disease and late hyporegenerative anemia. Her serum ferritin and bilirubin levels increased to 8842 ng/ml and 17.9 mg/dl, respectively. Liver biopsy ...
The wrong decision can upend your study in rare disease research — especially for clients developing an orphan drug. That’s why we take a holistic approach from the outset, accelerating study startup by providing an upfront understanding of data, cost and necessary clinical expertise for your ...
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The mean number of planned visits and days for follow-up are higher for rare disease compared to none-rare disease protocols. The coefficients of variation for both rare disease and non-rare disease protocols are generally very high–in particular those associated with patient recruitment and ...
Mucinous appendicular neoplasms are a rare and heterogeneous group of tumors, whose treatment may vary based on histologic features and extent. We present a case of low-grade appendiceal mucinous neoplasm mimicking an acute appendicitis scenario. The patient underwent appendectomy along with resection of...