In this review, we summarize the structure and regulation of isoforms of V-ATPase subunits and discuss their context-dependent roles in cancer biology and cell death. Updated knowledge about V-ATPases may enable us to design new anticancer drugs or strategies....
Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless...
In this review, we examine the different modes of cell death employed by the host during infection, the strategies used by pathogens to manipulate the cell death process and the outcome of cell death, that is, whether it is protective for the host or on the contrary favorable for pathogen ...
phagocytosis by phagocytes, limiting inflammation [5]. Apoptosis is regulated through differential expression of pro- and anti-apoptotic proteins, necessitating a strong enough trigger to shift the balance and effect cell death. Regulation of cell death is significantly perturbed in cancer, leading to ...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collage
Given all the evidence, it is clear that there is a need for an understanding of how the Hippo pathway deactivates in cancer. Although we observe RAS-MAPK suppression of the Hippo pathway at the signaling level, the fact is that the Hippo pathway enhances RAS-MAPK activity. When Hippo elim...
Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell junctions and acquire a mesenchymal cell-like phenotype (17). EMT is observed in some developmental processes as well as cancer invasion and metastasis. Snail, a transcriptional repressor, plays a central...
AAA-ATPases at the crossroads of protein life and death. Nat Cell Biol 1, E97–E98 (1999). https://doi.org/10.1038/12097 Download citation Issue DateAugust 1999 DOIhttps://doi.org/10.1038/12097 This article is cited by The peroxisome biogenesis factors posttranslationally target reticulon ...
Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the ph