Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cellsTwo proteins comprising the ZEB family of zinc finger transcription factors, ZEB1 and ZEB2, execute EMT programs in embryonic development and cancer. By studying regulation of their expression, we ...
#小普日报每天阅读一分钟,行业热点全知道☆ 关键词转录因子 激酶 大肠杆菌 TrkB受体 mGlu2受体 单细胞转录组学 度伐鲁单抗 CAR-T细胞 伊鲁阿克 阿得贝利单抗 今日行业热点#①Science:The transcription factor ZEB2 drives the formation of age-associated B cells ...
. MILIP physically interacts with Y-box binding protein 1 (YBX1) and enhances the translational activation of another EMT core transcription factor, Snail family transcriptional repressor 1 (Snai1) and other factors, such as matrix metallopeptidase 2 (MMP2), N-cadherin and Vimentin, and decreases...
including ERα, which is essential for the expression of ERα target genes and the development of estrogen-dependent tissues (Fig.3a) [100]. In addition, the transcription factor FOXA1 not only affects cell growth but also plays a regulatory role in endocrine ...
Integrating the results of these interference RNA screens and additional gene expression data, we identified the transcription factor ZEB2 as a novel AML dependency. ZEB2 depletion impaired the proliferation of both human and mouse AML cells and resulted in aberrant differentiation of human AML cells....
(CD-IC; SLC26A4, SCNN1A), connecting tubule-principal cell (CD-PC; AQP2, FXYD4, STC1), medullary collecting duct (MCD; UPK1B, UPK3A), MC (PDGFRB, CFH, ZEB2, COL12A1), podocyte (NPHS1, NPHS2), EC (PECAM1, CDH5), B cell (CD19), T cells (CD3E), NK cell (NCR1), ...
Consistent with these observations, the mRNA levels of Slug, ZEB1, and ZEB2—EMT-related transcription factors—increased significantly. Although the N-terminally deleted mutant LEF-1 cannot interact with β-catenin, it retained the ability to induce EMT. Consistent with these observations, neither ...
Nuclear localized SMAD2/3/4 complex induces tumor-promoting effects through cell proliferation (PDGF-β), immune suppression (Foxp3), EMT activation (SNAIL/SLUG, ZEB1/ZEB2, HMGA2), EMT suppression (E-Cadherin, Cytokeratin) and metastasis (HDM2, MMP-9). Tumor-suppressing effects inhibit cell ...
Here we show that, shortly after induction of EMT and while cells are still epithelial, ZEB1 modulates ERα-mediated transcription induced by estrogen or cAMP signaling in breast cancer cells. Based on these findings and our ex vivo and xenograft results, we suggest that the functional ...
Zeb2, Isl1, Rhox4b, Uncx,andHmx1were expressed in the secondary palate (Supplementary Fig. S6), suggesting that these homeobox transcription factors may be implicated in palatal development as intrinsic factors. Among these genes, ablation or mutation ofAlx3, Lhx8, Pax3, Pitx1,Shox2,andZeb2...