The basal transcription factor II H (TFIIH) is a multicomponent complex. In the present study, we characterized a TFIIH subunit Tfb5 by analysing loss- and gain-of-function mutants to gain a better understanding of the molecular mechanisms underlying stress resistance and pathogenicity in the citr...
The transcription factor Bach2 regulates the immune system at multiple points, including class switch recombination (CSR) in activated B cells and the function of T cells in part by restricting their terminal differentiation. However, the regulation of Bach2 expression and its activity in the immune...
Yin Yang 1 (YY1) is a multifunctional DNA-binding transcription factor shown to be critical in a variety of biological processes, and its activity and function have been shown to be regulated by multitude of mechanisms, which include but are not limited to post-translational modifications (PTMs...
M. et al. Transcription-factor-mediated supervision of global genome architecture maintains B cell identity. Nat. Immunol. 19, 1257–1264 (2018). Article CAS PubMed Google Scholar Chen, H. et al. Dynamic interplay between enhancer-promoter topology and gene activity. Nat. Genet. 50, 1296–...
Although the function of this region in ERM is partially relieved by cooperation with the transcription factor c-Jun [19], the precise mechanism of this inhibition is still unknown. The NRD is localized in the central region of the PEA3 group members between the acidic domain and the ETS ...
Functions and Application of the AP2/ERF Transcription Factor Family in Crop Improvement Plants have acquired sophisticated stress response systems to adapt to changing environments.It is important to understand plants' stress response mechanis... Zhao-Shi,Xu,Ming,... - 《Journal of Integrative Plant...
and C. Synteny analysis indicates that the firsts 3R-MYB gene was amplified through segmental duplications in Amborella. Gene duplications within these lineages after the separation of monocots and dicots are the important factor that explains the large diversity seen today. The general gene structure...
A Y1H assay technique was performed to confirm the interaction between the transcription factor (AlABD-B or AlUNC-4) and the promoter of theAlLuc1gene (proAlLuc1) (Fig.4E, F). The yeast one-hybrid results showed that Y1H Gold yeast cells containingpABAi-proAlluc1and pGADT7-AlABD-B ...
Endothelial cells actively maintain an anti-thrombotic environment; loss of this protective function may lead to thrombosis and systemic coagulopathy. The transcription factor ERG is essential to maintain endothelial homeostasis. Here, we show that induc
For example, the gene encoding the housekeeping σ factor RpoD is transcribed from two promoters and one of them is the RpoH-regulated heat shock promoter (29). Similarly, the rpoH gene is transcribed from multiple promoters whose transcription is regulated by different σ factors (3, 30). ...