IL-4 is known to be associated with Th2 immune responses, which are traditionally considered detrimental to fungal clearance. This result suggests that the presence of soluble dextran may modulate dendritic cell responses toward a Th2 phenotype, potentially impacting the immune defense against fungal ...
Expression of Daxx, Atrx and the other H3.3 chaperone Hira17 during haematopoiesis is enriched in long-term haematopoietic stem cells (LT-HSCs), megakaryocyte-erythrocyte progenitors and B cells (Extended Data Fig. 1a; based on18). To assess the impact of Daxx loss on the chromatin landscape ...
Genes of module 3 were enriched in myeloid cell differentiation, megakaryocyte differentiation, positive regulation of cell adhesion, small GTPase mediated signal transduction and erythrocyte differentiation. The dynamic expression of scores for representative pathway in module 1–3 are shown in supplemental...
The influence of erythrocytes and oxygen concentration on kidneys during long-term normothermic kidney perfusion is under debate. This study compares acellular and erythrocyte-based NMP with focus on oxygen delivery to the tissue as well as the effects of high oxygenation on tissue integrity. Pig ...
Each of these activities is executed in a location within a cell or in the vicinity of a cell. In order to capture this context, the GO includes a sub-ontology called the Cellular Component (CC) ontology (GO-CCO). The primary use of this ontology is for GO annotation, but it has ...
3.2.1Erythrocyte-Derived Bio-nanocarriers Amongst the nano-biocarriers, erythrocytes have gained significant attention from the scientific community due to additional advantages like large quantities of the cell membrane, high internal capacity volume (185–191 μm3), high biostability and biodurability...
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these eve
These observations strongly suggest that Neo is present in reticulocytes, but it has a short half-life in mature peripheral red cells. Erythrocyte and hemoglobin characteristics of β6I mice There was no significant difference between the RBC counts, hemoglobin concentrations (Hb), hematocrit values...
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to neutrophils from normal and inflamed mouse tis
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel no