During anaplerosis, α-KG enters the TCA cycle and produces OAA. In addition to its use as a source of OAA, glutamine carbon can be converted to lactate (glutaminolysis). This process generates both NADPH and NAD+ in the cytoplasm. Ammonia generated during glutamine metabolism is mostly ...
The TCA cycle could also be a central pathway that provides a unifying point for several metabolit...
A mutation in tctA affected the TCA cycle and conferred the inability to grow on minimal agar. The virulence of L664 was not attenuated. Ciprofloxacin exposure produced ROS in L664 and SL1344 (tctA::aph), but it was reduced and occurred later. There were no significant differences in the ...
Fumarate hydratase (FH) is a TCA cycle enzyme. Hereditary leiomyomatosis and renal cell cancer (HLRCC) are hereditary cancer syndromes characterized by the inactivation of FH. The inactivation of FH is induced and leads to cell death via ferroptosis. Mechanistically, the FH−/−sensitivity to f...
Tricarboxylic acid (TCA) cycle A series of enzymatic reactions that occur in a closed loop in the mitochondrial matrix. The TCA cycle completely breaks down glucose and oxidizes acetyl coenzyme A to generate the NADH and FADH2 that are required for the electron transport chain. Glycolytic metabolon...
Fig. 6). Since there is no SCC on weight level two which includes cumomers of pool SucCoA, only a single carbon atom may be kept on a cyclic path through all the pools of the TCA cycle. The graphs on weight levels 10 and 11 contain no edges at all, which indicates that the cum...
What does the Krebs cycle produce?Krebs cycleThe Krebs cycle, or TCA cycle is a chemical pathway that releases chemical potential energy from macromolecules such as carbohydrates and lipids and turns them into ATP via oxidative phosphorylation or the electron transport chain. This pathway produces ...
Also, for tumours with defective respiration (highly glycolytic, hypoxic tumours), glutamine oxidation produces significant energy through substrate level phosphorylation in the TCA cycle [14]. This occurs through the action of succinyl-CoA synthetase (SCS) Would glucose and glutamine deprivation kill ...
Moreover, children carrying autosomal recessive mutations of the Slc25a1 gene develop a severe neurometabolic disorder as a consequence of citrate deficit, hallmarked by the presence of two abnormal products of the TCA cycle, D2-, and L2-hydroxyglutaric acid (2-HG) [9, 10]. However, we ...
into glutamate, and glutamate dehydrogenase convers glutamate intoαKG to enter TCA cycle.114In some types of cancers like human pancreatic ductal adenocarcinoma (PDAC), glutamate and oxaloacetate (OAA) are transformed into αKG and aspartate. The aspartate can be converted into oxaloacetate by ...