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a.a region where nerve impulses are transmitted across a small gap from an axon terminal to an adjacent structure, as another axon or the end plate of a muscle. b.Also calledsynap′tic gap′.the gap itself. v.i. 2.to form a synapse or a synapsis. ...
The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectrosc...
Structure-based discovery of nonhallucinogenic psychedelic analogs. Science 375, 403–411 (2022). Article CAS PubMed Google Scholar Froldi, G., Silvestrin, B., Dorigo, P. & Caparrotta, L. Gramine: a vasorelaxing alkaloid acting on 5-HT2A receptors. Planta Med. 70, 373–375 (2004)....
Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has been made in elucidating the pathophysiologica
or they can pass upward here in the medial part of the inferior orbital fissure and pterygopalatine fossa up through the fissure into the orbital apex. But, commonly neurosurgery is involved when not only the orbit is involved but the adjacent structure. Also the closer the lesion is to the...
Neural syntax: cell assemblies, synapsembles, and readers. Neuron 68, 362–385 (2010). CAS PubMed PubMed Central Google Scholar Braitenberg, V. & Schüz, A. Anatomy of the Cortex (Springer, 1998). Google Scholar Shepherd, G. M. The Synaptic Organization of the Brain (Oxford Univ. ...
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the rece...
In recent years, exploring natural compounds with functional properties to ameliorate aging-associated cognitive decline has become a research priority to ensure healthy aging. In the present study, we investigated the effects of Trigonelline (TG), a plant alkaloid, on memory and spatial learning in...