The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell? 1. The metabolism of glucose and the exchangeable Ca2+ pool were measured in rat pancreatic islets, in order to assess the possible significance of glycoly... A, Sener,J...
The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATE Glucose-induced insulin release is thought to result from the following sequence of events in the beta cell: glucose metabolism leading to the production of...
Further, the stimulus-response extracellular insulin secretion system of the cells can be improved by transferring a Pdx-1 gene into the cells. The insulin-producing/secreting cells thus obtained are physiologically closely similar to islet 尾 cells and usable in treating or studying diabetes, etc....
Circulating IGF-1 is also considered critical for follicular maturation as it amplifies the gonadotropin stimulus [152,153]. Cows with low IGF-1 after calving therefore remain anovulatory for longer [154,155,156]. Overall, cows with a low nadir in IGF-1 in the first 2 weeks after calving ...
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyl...
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Among them, anti-apoptosis pathways and growth factor pathways are key pathways of fibroblasts, which are essential to convert an initial stimulus to the development of fibrosis. BCL-2 related proteins are key regulators of mitochondrial apoptosis and have long been identified for its role in ...
et al. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J. Biol. Chem. 274, 5830–5834 (1999). Article CAS PubMed Google Scholar Twigg, S. M. et al. Renal ...
As one of the main pathogenic factors of cardiovascular and cerebrovascular diseases, the incidence of metabolic diseases such as adiposity and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing annually. It is urgent and cruc
Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation of senescent cells, which develop the senescence-associated secretory phenotype (SASP). Here we show that procyani