Insulin secretion is triggered by a rise in the intracellular Ca2+concentration that results from the activation of voltage‐gated Ca2+channels in the β‐cell plasma membrane. Multiple types of β‐cell Ca2+channel have been identified in both electrophysiological and molecular biological studies, but...
Insulin secretion is triggered by a rise in the intracellular Ca2+concentration that results from the activation of voltage‐gated Ca2+channels in the β‐cell plasma membrane. Multiple types of β‐cell Ca2+channel have been identified in both electrophysiological and molecular biological studies, ...
Stimulus-secretion coupling of arginine-induced insulin release: comparison with lysine-induced insulin secretion. A, Malaisse-Lagae F, Malaisse WJ (1989a) Stimulus-secretion coupling of arginine-induced insulin release: comparison with lysine-induced insulin secretion... Sener,Blachier,Rasschaert,.....
These findings reinforce the view that the carrier-meadiated entry ofl-arginine into the islet B-cells, with resulting depolarization of the plasma membrane, represents the essential mechanism for stimulation of insulin release by this cationic amino acid.doi:10.1385/endo:13:3:329...
Give one example of humoral stimulus, neural stimulus, and hormonal stimulus for the release of hormones.What does the adrenal medulla secrete?The secretion of the adrenal medulla act to supplement the effects of ___. a. vagus nerve activity b. somatic nervous system c. parasy...
Except for the fall in ATP concentration and ATP/ADP ratio found at very low glucose concentrations (zero to 1.7 mmol/l) no effect of glucose (2.8-27.8 mmol/l) upon the steady-state concentration of adenine nucleotides was observed. However, a stepwise increase in glucose concentration ...
Goldfine, I. D.; Williams, J. A. Receptors for insulin and CCK in the acinar pancreas: Relationship to hormone action.Int. Rev. Cytol.85: 1–38, 1983. CASGoogle Scholar Hokin-Neaverson, M. Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid...
The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATE Glucose-induced insulin release is thought to result from the following sequence of events in the beta cell: glucose metabolism leading to the production of...
apparent Ca2+ sensitivity of exocytosis whereas it prevented the activity-dependent facilitation in GK rat β-cells.We conclude that a decrease in the apparent Ca2+ sensitivity of the GK rat β-cell release machinery is involved in defective glucose-stimulated insulin secretion o...
Somers G, Sener A, Devis G, Malaisse WJ (1980) The stimulus-secretion coupling of glucose-induced insulin release. XLV. The anion-osmotic hypothesis for exocytosis. Pflugers Arch 388:249–253Somers, G., Sener, A., Devis, G., and Malaisse, W.J., The stimulus-secretion coupling of ...