Thus, SBS1, ID1 and ID2 may all be generated during DNA replication at mitosis. The number of ID5 mutations correlated with the number of SBS40 mutations, and the mutational processes that underlie these two age-correlated signatures may therefore contain common components. ID8, which is ...
links to metastasis and tumor immune regulation.30However, despite these advancements, our understanding of CIN remains incomplete. The complex nature of CIN, its causes and consequences, as well as the paradox of CIN, necessitate a systematic review. This is particularly important, given the potent...
fertilization, and development of new organisms1,2. While the underlying cellular and molecular machinery is primarily conserved1, interspecific hybridization may disrupt the usual reproductive pathways. Such a disruption often reduces fertility in hybrids3,4,5. Nevertheless, hybridization...
We detected overexpression of FXYD2, a member of the FXYD family of transmembrane proteins that modulates the activity of the γ-subunit of the renal Na/K-ATPase, in the deeper medullary region, which enabled the cell to maintain its source of energy by increasing the apparent affinity for ...
of the nuclear envelope by the gradual deposition of lamin intermediate filaments, although a contribution from cell–cycle–specific forces cannot be ruled out (Chu et al.2017). Finally, as the cell enters mitosis, the nuclear envelope dissolves, and the nucleus as an entity ceases to exist ...
(XPC), which are involved in the synthesis of phosphoethanolamine38 (one of the most abundant phospholipids in cell membranes), mitosis and assembly of the nuclear pore complex,39 sorting of low-density lipoprotein receptor-related protein 1,40 mitochondrial ribosome, protein glycosylation,41 and ...
DNA methylation is significant for the development and plays an important role in gene silencing, protection against spurious repetitive element activity, genomic stability during mitosis, and parent-of-origin imprinting [1]. Moreover, alteration of the DNA methylation pattern caused by the environment...
Mitosis 是一个开发工具,允许开发人员编写一次组件代码,然后在多个前端框架上运行,例如 React、Vue、Angular 等。 Features: 特征: Framework Agnostic:Supports multiple front-end frameworks, ensuring broad compatibility of components. 框架无关:支持多种前端框架,确保组件的广泛兼容性。
The general translation is enriched on the spindle during mitosis and results in asymmetric protein accumulation To test if general mRNA translation is also increased on the micromere-side of the spindle, we visualized general translation activities in the cell using homopropargyl-glycine (HPG) or O...
et al. The importance of kinase-phosphatase integration: lessons from mitosis. Trends Cell Biol. 28, 6–21 (2018). Article CAS PubMed Google Scholar Nasa, I. & Kettenbach, A. N. Coordination of protein kinase and phosphoprotein phosphatase activities in mitosis. Front. Cell Dev. Biol. 6...