the Signaling Pathways Project (SPP), that enhances the FAIR status of public cell signaling ‘omics datasets along three dimensions. Firstly, SPP encompasses datasets involving genetic
Integrated mining of public transcriptomic and ChIP-Seq datasets has the potential to illuminate facets of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates stable community ...
Orange triangle: pathway Disease pathways: pathways in cancer; metabolic pathways; chemical carcinogenesis-receptor activation; PI3K/Akt signaling pathway. OSCC: oral squamous cell carcinoma 图3 白藜芦醇-OSCC-靶点-通路网络图 Full size|PPT slide 2.3 白藜芦醇与OSCC关键靶点蛋白分子对接验证 将PPI 网络...
Li initiated a project to tag every protein in mice based on SC technology (genome tagging project, GTP), which may enable the precise deion of protein atlas in mice.
多个浏览器通过Web服务器访问网站,浏览器之间的通话并不通过任何流媒体服务器,而是直接通过对等连接,通过UDP来实现浏览器之间的通信。这个叫做全网状模型。 第二种实现方式:浏览器和媒体服务器建立对等连接——集中式模型 服务端除了Web服务器之外还需要架构一个台媒体服务器,媒体服务器和各个浏览器之间实现对点连接。
8 As an effective therapeutical method, radiotherapy was recognized as an indispensable treatment in PCa and its curative effect correlates with the radiosensitivity of tumors; however, the signaling pathways in PCa to radiotherapy was still perplexing, which needs further inv...
Particularly for CRC, the Cancer Genome Atlas project found that the Wnt signaling pathway was altered in 93% of all tumors Citation[13]. It is no surprise therefore that substantial effort is focused on how to develop Wnt signaling inhibitors. However, development of targeted drugs to disrupt ...
Figure 4.The unique gene signatures and signaling pathways in BPH. PPI, protein–protein interaction; DEGs, differential expression of genes; BPH, benign prostate hyperplasia; CaP, prostate cancer; CRPC, castration-resistant prostate cancer; G.O., gene ontology. ...
which occurs in a disorganized pattern alongside heightened fibroblast proliferation rates and heightened sensitivity to growth factors (Citation16,Citation17). Variations in growth factor production could be attributed to epithelial-mesenchymal interactions, the retention of fetal proliferative pathways, or th...
Numerous studies have shown that cinnamon and turmeric have various health benefits, including the reduction of insulin resistance and insulin signaling pathways in diabetic patients, the reduction of inflammatory biomarkers, and the maintenance of gut microflora in both animals and humans. The food and...