The shape and structure of proteinsAlberts, BruceAlberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002) The shape and structure of proteins. In: Molecular biology of the cell. Garland Sciences, New York, Fig. 3.1
The field of structural genomics aims to reveal the shapes of proteins by using the information obtained from genome-sequencing projects in automated, high-throughput schemes. These would synthesize thousands of proteinsin vitroso that they could be examined by X-ray crystallography and nuclear magneti...
NATURE|Vol435|2June2005 Proteinstructureshintat theshapeofthingstocome Inlessthanayear,anAnglo-Canadiangroup hasworkedoutthestructuresof50complex proteinsthatarerelevanttohumandisease. Therecentexplosionofgenomesequence dataledscientiststohopethatworkingout proteinstructurescouldbecomeautomated andaccelerated.Todate...
TheProteinsXiangweiGao(高向伟)xiangweigao@ BioelectromagneticsLabotary,ZhejiangUniversity,SchoolofMedicneResearchBuildingB203WhyDoWeStudyProteins?ProteinsarecodedbygenesTheyplaycrucialfunctionalrolesinalmosteverybiologicalprocessTheLifeCycleofAProtein翻译成熟糖基功能调节磷酸化执行功能结构功能降解Wheredoesaproteincomefrom?
Cells of the budding yeast Saccharomyces cerevisiae are born carrying localized transmembrane landmark proteins that guide the subsequent establishment of ... Tong,Zongtian,Gao,... - 《Journal of Cell Biology》 被引量: 168发表: 2007年 A new family of global protein shape descriptors A family of...
Determine protein complexes size, molecular weight and degree of folding Access the structure of intrinsically disordered proteins and RNA and quantify movements of flexible domains Analyze the structure of liquid crystals in lipid drug delivery systems. Determine size and shape of micelles or surfactants...
There are over 20,000 different proteins in the body (1). How do proteins have so much functional diversity based upon only 20 building blocks? The answer lies in the complexity of primary, secondary, tertiary, and quaternary structure (Figure 1). Figure 1. The four levels of protein ...
AlphaFold can predict the structure of single- and multiple-chain proteins with very high accuracy. However, the accuracy decreases with the number of chains, and the available GPU memory limits the size of protein complexes which can be predicted. Here we show that one can predict the structure...
After the separation of proteins by electrophoresis, the gel was stained with Coomassie brilliant blue G-250 to visualize all proteins. Selected subunits were identified by SDS-PAGE and liquid chromatography with tandem mass spectrometry (LC-MS/MS). In-solution and in-gel digestions for LC-MS/...
The recognition of specific DNA sequences by proteins is thought to depend on two types of mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations