The mutant gained a substantial amount of stability compared to the wild-type protein and its structure is fully preserved. Its ability to dimerize is considerably impaired. Conformational dynamics of the mutant are stalled, in contrast to the wild-type protein. Our results show that Met side ...
et al. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886–1889 (2002). CAS PubMed Google Scholar Buckley, D. L. et al. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1alpha. Angew. Chem. Int. Ed. Engl...
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several studies have also found that dysbindin-1 gene and protein expression are altered in two affected brain ar
is often indicative of the importance of the position in maintaining the protein's structure and/or function.ConSurf is a web-server (http://consurf.tau.ac.il/) for mapping the level of evolutionary conservation of each of the amino-acid positions of a protein onto its 3D structure (1)...
peptidomimetic or small-molecule compounds has been explored as a therapeutic approach for MLL1-r leukemia. This review summarizes the biological functions, biochemistry, structure and inhibition of the critical PPIs involving MLL1 and its fusion partner proteins. In addition, challenges and perspectives...
Fig. 1: Aspect ratio controls the coordination and rotational restriction of the building block, altering the protein network rigidity. a Crystal structure of protein L (PDB code: 1HZ6) and a schematic depicting the increasing aspect ratio (AR) of polyprotein building blocks as an increase in ...
Molecules that covalently engage target proteins are widely used as activity-based probes and covalent drugs. The performance of these covalent inhibitors is, however, often compromised by the paradox of efficacy and risk, which demands a balance between
we describe the design and characterization of a stabilized protein tertiary structure that acts as an inhibitor of the interaction between the transcription factor TEAD and its co-repressor VGL4, both playing a central role in the Hippo signalling pathway. Modification of the inhibitor with a cell...
The model includes five modules: Input, Tokenizer, Encoder, Pooling, and Output. Its architecture is shown in Figure 1. Figure 1 The Architecture of LucaProt 3) Model Input/Output Use the amino acid letter sequence as the input of our model. The model outputs the function label of the ...
There are four levels of protein structure: Primary Structure: The primary structure of a protein is its amino acid sequence. This amino acid sequence is determined by the base sequence of the gene which codes for the protein. Secondary Structure: Secondary structures have α-helices and β-plea...