S100 protein familyLung cancerS100A2S100BS100A6The S100 protein family is involved in the pathogenesis of several malignancies including lung cancer. Recent studies have shown that one member, S100A2, was over-
Hepatocellular carcinoma (HCC) is a common malignant tumor with a complex immune evasion mechanism posing a challenge to treatment. The role of the S100A10 gene in various cancers has garnered significant attention. This study aims to elucidate the impac
The S100 protein family, as a Ca2+ sensor, regulates many activities inside and outside the cell in a Ca2+-dependent manner [6]. By binding with Ca2+, conformational changes occur, exposing the binding site to the target protein and resulting in biological effects, such as regulation of gen...
BMC Cancer (2015) 15:199 DOI 10.1186/s12885-015-1217-x TECHNICAL ADVANCE Open Access A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours Juan Martínez-Aguilar1,2, Roderick Clifton-Bligh3 and Mark P Molloy1,2* ...
Thus, we aimed to investigate S100A11 functions within cancer cells, primarily focusing on colorectal cancer cells, whose S100A11 is abundantly present in cells and still poorly studied cancer for the protein. Our efforts revealed that overexpression of S100A11 promotes proliferation and migration, ...
Although there is little direct evidence supporting that stress affects cancer incidence, it does influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in human epidemiological analyses and mouse models. The experience of and response to physiological and psychological stress...
(2017) 15:7 DOI 10.1186/s12964-016-0161-y REVIEW Open Access The Id-protein family in developmental and cancer-associated pathways Cornelia Roschger and Chiara Cabrele* Abstract Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-...
The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. Methods Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in ...
S100A4 protein represents an important member of the S100 family of small calcium-binding proteins [8,9]. Interacting with several target proteins, S100A4 affects a number of activities, accelerating tumorigenesis and in- vasion of human cancers. At the molecular and cellular level, the cancer-...
Cancer Gene Therapy volume 30, pages 529–547 (2023)Cite this article 4316 Accesses Metrics details Abstract Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological ...