Steketee JD, Sorg BA, Kalivas PW (1992) The role of the nucleus accumbens in sensitization to drugs of abuse. Prog Neuro psychopharmacol 16:237-246Steketee JD, Sorg BA, Kalivas PW: The role of the nucleus accumbens in sensitization to drugs of abuse. Prog Neuro- psychopharmacol Biol ...
The nucleus accumbens (Nac) is optimally situated to allow influences from both the cortex and limbic regions to modulate the behavioral expression of stimulus–reward associations and has been shown to be particularly sensitive to the enhance- ment of responding for a CRf using the psychomotor ...
Nucleus accumbens dopamine plays a key role in reward‐directed approach. Past findings suggest that dopamine''s role in the expression of learned behavior diminishes with extended training. However, little is known about the central substrates that mediate the shift to dopamine‐independent reward app...
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res. Rev 1999;31:6-41. [PubMed: 10611493]Ikemoto, S.; Panksepp, J. The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation ...
We hypothesized reduced volume of the nucleus accumbens (NAcc), reduced structural connectivity of the segment of the supero-lateral medial forebrain bundle connecting the orbitofrontal cortex (OFC) with the NAcc (OFC-NAcc), and reduced resting-state OFC-NAcc functional connectivity (FC). ...
Likewise, local application of the D1 agonist SKF 38393, in combination with a subthreshold dose of MK-801 given intraperitoneally, point to an important role of the accumbens nucleus in motor control.Previous experiments based on systemic drug administration have also shown a synergistic interaction...
The nucleus accumbens (NAc) has an important role in the reward system and receives orexinergic projections of the lateral hypothalamus. In addition, orexin interacts with other receptors that are involved in drug reinstatement. Therefore, in the present study, the role of orexin receptors in the...
Its expression in the nucleus accumbens in response to chronic stimulation of the reward system triggers neuroplasticity in this system. Although δFosB expression increases in response to many different stimuli, its exact effects differ depending strictly on the brain region and type of neurons in ...
A number of alterations in glutamatergic transmission occur within the nucleus accumbens after withdrawal from chronic drug exposure. These drug-induced neuroadaptations serve as the molecular basis for relapse vulnerability. In this review, we focus on the role that glutamate signal transduction in the...
In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspec...