Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyl...
The plasma membrane of a cell undergoes continuous deformations and turning-over of its constituents required for a diverse set of functions. And yet, the
The ER is also the major site for the synthesis of sterols and phospholipids that constitute the bulk of the lipid components of all biological membranes. In addition, many enzymes and regulatory proteins involved in lipid metabolism reside in the ER. The ER, therefore, plays an essential role...
The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the...
The role of lipid membranes in life's origin. Life (Basel). 7:E5. https://doi.org/10.3390/life7010005Deamer, D. The role of lipid membranes in life's origin. Life 7, 5 (2017).Deamer, D., 2017. The role of lipid membranes in Life's origin. Life. Biology(...
role for the gut microbiome in influencing remote organs, mucosal, and immune function [3,4]. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome–...
About lipid metabolism in Hermetia illucens (L. 1758): on the origin of fatty acids in prepupaeZoologyEntomologyAlthough increasingly targeted in animal nutrition, black soldier fly larvae or prepupae (BSF,L. 1758) require the characterization and modulation of their fatty acid profile to become ...
In addition, activation of these nuclear hormone receptors would also stimulate the formation and packaging of lipids required for the formation of the extracellular lipid membranes. Thus, activation of PPARs and LXRs could provide a mechanism to coordinate the formation of the corneocytes and ...
Considering the irreplaceable role of brain in human activities, it is of great importance to further explore the impacts of microgravity and underlying mechanism on brain. Due to the high cost, low frequency and technical difficulties of space experiments, ground-based simulated microgravity (SM) ...
SINCE Hirsch's1 theory of the Golgi presubstance, according to which there exist homogeneous granular mass as a precursor of the ‘Golgi’ system, there has been very little attempt to investigate the origin of these inclusions in the cell. Nath and Chopra2 reported the origin of ‘Golgi dict...