The role of basophil-cytokine networks in asthma. In: Marone G, Austen KF, Holgate ST, Kay AB, Licht- enstein LM, editors. Asthma and allergic diseases: physiology, immunophar- macology, and treatment. San Diego (CA): Academic Press; 1998. p. 75-84.Schroeder, John T., " The Role...
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in the nucleus or the cytoplasm, or can be secreted into the extracell
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) and cardiotrophin-like cytokine factor 1 (CLCF1). Membership of this cytokine family is defined by usa...
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19 Abstract A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. ...
The prevalence, morbidity, and mortality of inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are increasing in women. There is a dearth of data on the biological mechanisms to explain such o
In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which are dependent on IL-10, TGF-β, retinoic acid, indoleamine-2,3,-dioxygenase along with vitamin D. Several of these mechanisms are employed by ...
However, IL-25 pioneers gene expression in other tissues and pathological changes in mucosal tissues, which have also attracted great deal of attention [10]. Some data support critical role of IL-25 in the pathogenesis of asthma. In sensitized murine lungs, increased levels of IL-25 have been...
IL-17A, the prototypical member of this family, just passed the 25th anniversary of its discovery. Although less is known about IL-17B–F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Over the past decade, however, it ...
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstrea
The role of IL-1 family members and Kupffer cells in liver regeneration. BioMed Res. Int. 2016, 6495793 (2016). PubMed PubMed Central Google Scholar Gehrke, N. et al. Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation. J. Hepatol. ...