Wang L, Zuo X, Xie K et al.: The role of CD44 and cancer stem cells. Methods Mol Biol 2018; 1692: 31-42.L. Wang, X. Zuo, K. Xie, and D. Wei, "The role of CD44 and cancer stem cells," in Cancer Stem Cells, vol. 1692 of Methods in Molecular Biology, pp. 31-42, ...
CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer. Systematic comparison of their functions is still lacking. We investigated the expression of CD44, CD24 and ALDH...
The clinicopathological impacts of CD44s and its isoforms in promoting tumorigenesis suggest that CD44 may be a molecular target for cancer therapy (13). In addition, the established role of CD44 in maintaining stemness and the function of cancer stem cells in tumor regeneration following therapy s...
The role of CD44 and cancer stem cells. Cancer stem cells: methods and protocols. New York: Springer New York; 2018. p. 31–42. Wu R-L, Huang L, Zhao H-C, Geng X-P. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017;143:1–16. Article CAS PubMed Google ...
CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types including cancer stem cells and frequently shows alternative spliced variants that are thought to play a role in cancer development and progression. Hyaluronan, the main ligand for CD44, binds to and activates CD44...
Exploring the role of cancer stem cells in radioresistance Nat Rev Cancer, 8 (2008), pp. 545-554 Google Scholar [5] T. Lapidot, C. Sirard, J. Vormoor, B. Murdoch, T. Hoang, J. Caceres-Cortes, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mic...
Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metastasis. Extracellular vesicles (EVs) are nano-sized particles released by different kinds ...
ATL cells adhering to NECs down-regulated CD25 expression and enhanced vimentin expression, suggesting that most ATL cells acquired a quiescent state by cell-cell interactions with NECs. ATL cells adhering to NECs displayed highly elevated expression of the cancer stem cell marker CD44. Blockade ...
Cancer stem cells (CSCs) are the cancer cells that are responsible for initiation, progression, metastasis, therapy resistance and recurrence in various cancers, including colorectal cancer. The aim of this chapter is to discuss the mechanisms responsibl
Emerging Role of CD44 Variant 6 in Driving the Metastatic Journey of Ovarian Cancer Stem CellsIn recent history, cancer stem cells have been postulated as the driving force for carcinogenesis and the seeds of metastasis in several types of solid cancers. In addition, accumulating evidence......