The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that cont...
Functional characterization of novel circular RNA molecule, circzip-2 and its synthesizing gene zip-2 in C. elegans model of Parkinson’s disease. Mol. Neurobiol. 55, 6914–6926 (2018). Article CAS PubMed Google Scholar Tagawa, T. et al. Discovery of Kaposi’s sarcoma herpesvirus-encoded ...
The Q protein of bacteriophage λ is a transcription antiterminator that modifies the elongation properties of E. coli RNA polymerase (RNAP). To do this, DNA-bound λQ must first engage a paused elongation complex. Here we show that this engagement of λQ with RNAP involves an interaction ...
A transcribed non-naturally occurring RNA molecule comprising a desired RNA molecule, wherein the 3′ region of the RNA is able to base-pair with at least 8 bases at the 5′ terminus of the same RNA molecule.James D. ThompsonUSUS6852535 2000年8月2日 2005年2月8日 Sirna Therapeutics, ...
It has been reported that atypical protein kinase C (PKCλ/ι) is a crucial signaling transduction molecule functioning to regulate and maintain Th1/Th2 homeosta- sis. The level of IL-4, a Th2 cell cytokine, was downregu- lated in PKCλ/ι-knockout mice, while the level of IFN-γ,...
If a codon on an mRNA molecule is GGA, what is the anticodon on its matching tRNA molecule? a) GGU b) CCT c) AAC d) CCU tRNA Molecule A particular class of RNA molecule known as tRNA (transfer RNA) is essential for the production of ...
“The Catalyst” looks at RNA’s role in life’s origins as well as its medical uses The Catalyst. Thomas Cech. W.W. Norton; 304 pages; $28.99 and £23.99 What you see depends on how you look. For years students of cell biology were taught that...
5). There are also increasing interests in the development of 5′- or 3′-conjugates where a particular ligand or drug or targeting molecule (e.g. folate, N-acetylgalactosamine or GalNAc, etc.) is connected to the RNA molecule through a versatile linker (Dohmen et al., 2012; Foster et ...
The meaning of RNA is any of various nucleic acids that contain ribose and uracil as structural components and are associated with the control of cellular chemical activities.
Importantly, a systematic characterization of translational control and its links to other aspects of RNA metabolism in metastasis is still lacking. In this Article, we applied genome-wide experimental and computational approaches to address the changes in mRNA translation that accompany metastatic ...