It is widely held that the immune system evolved for maintaining the health of an individual. Health promotion is achieved through the ability of immune competent T-cells to recognize pathogens and respond to them, in a manner causing elimination of the
Subtypes are labeled by colors (right). g, A 2D graph of the pseudotime-ordered T&S cells from the young, middle and older age groups. The cell density distribution is shown in the above figure. h, Gene set score analysis of cellular senescence pathways in T&S subtype cells with age. ...
3-Hydroxybutyrate, a key constituent of ketone bodies, has been found to favor improvements in cardiovascular disease. However, whether the protective effect of diabetes on aortic dissection is mediated by 3-hydroxybutyrate is unclear. We aimed to investigate the causal effects of diabetes on the ...
leading to an increase in the secretion of inflammatory molecules. Tissue-resident macrophages, largely activated by adipocyte-derived FFAs via TLR or NOD-like receptor family, pyrin domain-containing 3 (NLRP3) pathways, release cytokines that inhibit insulin action in metabolic organs...
negatively charged insulin and polymers, promoting the rapid release of insulin. This proof-of-concept demonstration may aid the development of other translational stimuli-responsive microneedle patches for drug delivery. Access options Access Nature and 54 other Nature Portfolio journals...
The partial mechanisms by which cold exposure activates UCP1. Upon exposure to cold temperatures, both animals and humans trigger the activation of the sympathetic nervous system (SNS). This leads to the release of catecholamines (CAs) from the sympathetic nerves that innervate BAT, consequently ini...
Adipose tissue response to endocrine stimuli, such as insulin, is crucial for metabolic adaptation at the onset of lactation in dairy cows. However, the exact molecular mechanisms behind this response are not well understood. Thus, the aim of this study was to determine the dynamics in protein ...
Figure 1. VDAC1 is overexpressed in human colon pathologies and in DSS-treated cells, which result in VDAC1 oligomerization, apoptosis, and mtDNA release that are inhibited by VBIT-12 Immunohistochemical (IHC) staining of VDAC1 was performed on tissue microarray slides obtained from Biomax US (...
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular an
TMEM219 is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3)16,17. Indeed, IGFBP3 acts as a carrier of nearly 95% of insulin-like growth ...