Powerful genetic tools in the fruit fly Drosophila melanogaster have identified — at an unprecedented level of detail — genes and neural circuits that regulate sleep. This research has revealed that the functions and neural principles of sleep regulation are largely conserved from flies to mammals....
BackgroundAlthough sleep is an important process essential for life, its regulation is poorly understood. The recently developed ResultsWe generated or obtained flies with genetically altered expression of each of three ConclusionsThese data show that serotonin promotes baseline sleep in Drosophila. They ...
0023 Neuropeptidergic Regulation of Drosophila Larval Sleep INTRODUCTION. Sleep during early life is thought to be important for brain development. Indeed, disruptions in sleep during development have long-lasting effects on cognitive functioning. Recently, our lab has developed the LarvaLodge pl... AR...
Germ-free flies do not have activity or sleep defects. (A) Activity measured as photobeam crossings using theDrosophilaActivity Monitoring System (DAMS) assay for group housed F1 CV and GF flies. (B) In the day, GF flies made an average of 1.09 crossings/min (N = 59), while CV ...
This development opens up the possibility of applying genetic analysis to the identification of key molecular components of sleep. A mutant of monoamine metabolism has already been found to affect the homeostatic regulation of sleep-like behavior in the fly. The record of Drosophila in laying the ...
Fig. 1: Social attraction in Drosophila melanogaster. a Procedure for quantifying social approach behaviour. Immobilized attractor flies were tethered to the right side of a shallow dish while the left side was empty. The distribution of free-walking flies in the dish was tracked using a video ...
Our studies provide evidence for serotonergic signaling in the regulation of Drosophila sleep, identify a receptor that specifically functions in this process, and suggest that two serotonin receptor subtypes, d5-HT1A and d5-HT1B, mediate effects of serotonin on different behaviors in distinct ...
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S. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10, 409–426 (1993). CAS PubMed Google Scholar Dickson, B. J. & Gilestro, G. F. Regulation of commissural axon pathfinding by slit and its Robo receptors. ...
TRPA1 Circuit and the Regulation of Siesta Sleep In the year 2000, Drosophila melanogaster was established as a model to study sleep [46,47]. Since then, there is accumulating evidence that Drosophila sleep shares essential features with mammalian sleep [48,49], which makes the use of this ...