Targeting platelet receptor function in thrombus formation: The risk of bleeding AbstractIn this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis ... F Swieringa,MJE Kuijpers,JWM Heemskerk,... - 《Blood Re...
Traditionally, the focus has been on platelet activation, with the assumption that once the platelets are activated the process of thrombus formation is self-generating and irreversible. Here, we address mainly the question of platelet activation, mostly relevant for lower shear-rate situations. ...
Alterations in arterial blood flow are thought to predispose to thrombus formation, but the exact relationships have not been fully elucidated. The effect of varying blood flows on the accumulation of thrombotic material within arteries was investigated, with use of shear rate as an index of flow ...
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of ...
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An overview of antithrombotic therapy Many of the common problems in clinical practice today relate to thrombosis. The underlying final pathophysiological process in myocardial infarction and s... AD Blann,MJ Landray,GYH Lip - 《British Medical Journal》 被引量: 280发表: 2002年 Antithrombotic ...
This leads to increased LV wall stress, and myocardial oxygen demands as well as the stasis of blood in the aortic root with a potential risk of thrombus formation. Also, elevated LVEDP may result in pulmonary edema, pulmonary hemorrhage, systemic, cerebral, and myocardial hypoxia. The risk of...
GO Gene ontology, BP biological process, CC cell composition Full size image Fig. 7 a KEGG analysis of key target genes, b Network of top 20 pathways. Red diamond represents gene, and green triangle represents pathway. The size of the nodes represents the value of the degree. The ...
However, it is important to note that the process of rupturing the balloon of the Pivot-Mandu with a needle should be added to the process of device retrieval. In summary, our novel design of the Pivot-TR (Pivot-Mandu) system represents a significant advancement in the concept of long-...
MMPs are highly expressed in the synovium, synovial fluid, and peripheral blood of RA patients, and play a significant role in the process of joint inflammation and cartilage destruction. MMP-1 and MMP-3 are involved in joint damage, with MMP-3 being a key protease causing joint injury61, ...