Another line of evidence involves suppressed expression of the MITF master regulator of melanocyte differentiation, which is evidently involved in the genesis of aggressive forms of malignant melanoma. Loss of this developmental TF is associated with the reactivation of neural crest progenitor genes and ...
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. Here we review recent mRNA–protein correlation st...
.Expression of gene involves transcription and translation for both.Control of Gene ExpressionFeature EColi Gene Expression Eukaryotic GeneExpressionGenome Level Chromatin modification e.g. histone acetylationcannot Chromatin modificationoccur as prokaryotic DNA is not associated with e.g. histone acetylation...
Large-scale quantitative analysis of transcriptional co-expression has been used to dissect regulatory networks and to predict the functions of new genes discovered by genome sequencing in model organisms such as yeast. Although the idea that tissue-specific expression is indicative of gene function in...
Gene expression involves two major steps: transcription and translation (Fig.1a). Transcription is the process in which mRNA is synthesized by RNA polymerase using DNA as a template. The transcription rate of a geneitherefore depends on the number of RNA polymerasesnand its effective gene copy num...
of the Delta-Notch signalling pathway. In this process, each cell signals to inhibitac/scexpression in adjacent cells of the cluster. A single cell (the SOP) eventually retainsac/scexpression at a high level, although the mechanism of this singling out is still not well understood [9]. ...
Somatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are still largely unclear. Recent advances in single-cell technol
infestans. To uncover the underlying process, we investigated the dynamic gene expression profiles and the functions of the differentially expressed genes (DEGs). Results The results showed that the numbers of up-regulated DEGs were 1345, 1063 and 1694 in Q9 and 272, 603 and 2554 in Atl at ...
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel no
In the current study, we first performed a transcripotme meta-analysis to identifiy master-key responsive genes involved at the three stages of the lactation process. Then, the results of the meta-analysis were integrated into system biology approaches, i.e., weighted gene co-expression network...