Genome-wide analysis of gene expression is the study of transcription at a genomic scale, also known as transcriptomics. Typically relying on data from microarrays or high throughput sequencing, it can determine what genes or transcript isoforms are enriched in a particular cell or tissue type, con...
Gene expression in the nervous system refers to the regulation of mRNA synthesis and degradation, allowing for precise control over the levels of specific mRNAs involved in neural functions. This regulation involves posttranscriptional modifications and coordination between transcription and mRNA turnover to...
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims t
expression data themselves into what they call ‘minimal decision rules’ [5]. The basic idea is that genes with a similar expression profile are more likely to be part of one active biological process than genes with distinct expression profiles. These are only the early implementations of GO ...
Various mechanisms, such as transcriptional bursting, chromatin modifications, and feedback loops, can contribute to gene expression noise. 中文翻译过来就是: “基因表达噪音是指群体中单个细胞之间基因表达水平的变化,即使这些细胞的基因完全相同。这种噪音有多种来源,如转录率、翻译率和蛋白质降解率的波动。
Co-expression correlations provide the ability to predict gene functionality within specific biological contexts, such as different tissue and disease conditions. However, current gene co-expression databases generally do not consider biological context.
A common observation in the analysis of gene expression data is that many genes display similarity in their expression patterns and therefore appear to be co-regulated. However, the variation associated with microarray data and the complexity of the experimental designs make the acquisition of co-exp...
were not part of the training compounds that are known to be active for these specific targets based on information from the Drug Repurposing Hub51. In this sense, the model is doing what it is meant to do: connecting chemistry and biology through gene expression without the need of previous...
Gene drives are genetic modifications designed to propagate in a population with high efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be restricted to sexual organisms. Here, we report on a gene drive system that
The term epigenetics refers to inherited changes in gene expression that are not induced by changes in the DNA sequence itself. The DNA methylation mechanism is one of the earliest and most extensively studied types of epigenetic regulation [4]. Its association with developmental processes, aging, ...