Although these therapies represent a major advance in dry eye therapy, they are not effective in improving discomfort and corneal epithelial disease in all patients. Preclinical studies have identified other potential therapeutic targets, biomarkers, and strategies to bolster endogenous immunoregulatory ...
The pathophysiology of dry eye disease: What we know and future directions for research. Ophthalmology. 2017;124:S4–13. Article PubMed Google Scholar Uchino M, Schaumberg DA. Dry eye disease: Impact on quality of life and vision. Curr Ophthalmol Rep. 2013;1:51–7. Article PubMed PubMed...
IntroductionDry eye disease (DED) is a very common ocular condition with a considerable socioeconomic impact affecting patient's visual function and quality of life. Currently, thanks to the better knowledge on DED pathophysiology, therapeutical approaches are focused on the primary core mechanisms of...
understanding of the contributing and pathogenetic factors responsible for dry eye provides a rationale for multiple therapeutic options for this multi-factorial disease. In the elderly patient it is important to recognize the physical and cognitive limitations that will influence the selection of appropria...
Clinical Ophthalmology Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Dry Eye Disease in the Middle East and Northern Africa: A Position Paper on the Current State and Unmet Needs Sihem Lazreg 1, Mohamed Hosny 2, Muhammad A Ahad3, Mazen M Sinjab ...
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inflammationDry eye disease (DED) is a common, multifactorial ocular condition with major impact on vision and quality of life. It is now well recognized that the pathophysiology of chronic DED can include a cycle...doi:10.1111/aos.13436Baudouin, Christophe...
Calonge, M.,et al.Dry eye disease as an inflammatory disorder.Ocular Immunology and Inflammation.18(4), 244-253 (2010). Pflugfelder, S. C., de Paiva, C. S.The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research.Ophthalmology.124(11S), S4-S13 (2017...
Advances in understanding the pathogenesis of primary Sjogren’s syndrome. Nat. Rev. Rheumatol. 9, 544–556 (2013). Article CAS PubMed Google Scholar Pflugfelder, S. C. & de Paiva, C. S. The pathophysiology of dry eye disease: what we know and future directions for research. ...
In addition, to review the evidence for the role of tear osmolarity in the pathophysiology of DED and ocular surface disease. Methods: A literature review of all publications after the year 2000, which included the key- words "tear osmolarity", was conducted. Relevant articles were graded ...