Pathogenesis of dry eye in leprosy and tear functions. Int J Lepr Other Mycobact Dis 69(3): 215-8Koshy S, Daniel E, Kurian N, Yovan P. Pathogenesis of dry eye in leprosy and tear functions. Intern J Lepr Other Mycobact Dis. 2001;69(3):215-8....
Dry eye disease: an immune-mediated ocular surface disorder. Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis... W Stevenson,SK Chauhan,R Dana - 《Archives of Ophthalmology》 被引量: 393发表...
Recent evidence suggests an important role of androgens in regulating tear film secretion onto the ocular surface. In addition, inflammatory processes of the ocular surface seem to be the common final pathway of all chronic forms of dry eye. Novel concepts of pathogenes...
Pathogenesis of dry eye in leprosy and tear functions. Seventy-five leprosy patients and an equal number of age- and sex-matched controls were examined for tear functions, using Schirmer's test and tear break u... S Koshy,E Daniel,N Kurian,... - 《International Journal of Leprosy & Other...
biochemical events completes PARP-1-mediated necrotic death of cells, parthanatos, which has been impli- cated in various age-related neurodegenerative diseases.39,40 This observation led us to examine whether parthanatos is also involved in the pathogenesis of dry AMD, a prevalent senile eye ...
Localized disease Dry Eye is by far the most common autoimmune condition affecting the ocular surface. The estimated prevalence of Dry Eye ranges from 0.3 to 33% of the population depending on the definition and the population studied.30 Dry Eye can have a considerable effect on visual function...
potentially linked to neovascularization induced by EVs under oxidative conditions [157]. Moreover, mice exposed to photo-oxidative damage, known as an animal model of dry AMD, exhibit a decrease in the levels of miR-124-3p, which is known to be present in small EVs and play a key role ...
Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model ArticleOpen access13 August 2020 Main High-mobility group box 1 (HMGB1) is a nuclear protein that binds to DNA functioning as a DNA chaperone.1Various conditions such as acetylation,...
and 11% in the placebo arm in the two studies, respectively. The rates of achieving EASI75 were 59 and 51% in the lebrikizumab arm and 16 and 18% in the placebo arm in the two studies, respectively. Conjunctivitis and dry eye symptoms were the most commonly reported adverse events [77]...
of ocular disease3. Although previous studies of the involvement of inflammation has been limited to the pathogenesis of inflammatory disorders such as uveitis and dry eye disease (DED)3,4, it is now widely implicated in many other ophthalmic pathologies1. Thus, understanding of key inflammatory ...