In the past 10 years, the US Food and Drug Administration has approved at least 30 prodrugs, which accounts for more than 12% of all approved small-molecule new chemical entities. In this Review, we highlight prodrug design strategies for improved formulation and pharmacokinetic and targeting ...
By possessing chemical knowledge, our generative framework overcomes the limitations of current molecule generation models that rely on a small number of reaction templates. In extensive experiments, our model generates synthesizable drug-like structures of high quality. Overall, our work presents a ...
6.1.1thecharacterofpolymericchemicalreactionThemolecularweightisverylargePolydispersityandmulti-levelofstructureTheaggregativestructureandsolutionbehaviorofpolymerarefairlydifferentfromthoseofthesmallmoleculeThechemicalreactionofpolymerhavedifferentcharacterwithsmallmoleculecompound6.1thecharacterandinfluec(1)thechemicalreactions...
The automated synthesis of small organic molecules from modular building blocks has the potential to transform our capacity to create medicines and materials. Disruptive acceleration of this molecule-building strategy broadly unlocks its functional potential and requires the integration of many new assembly ...
is positively proportional to the mass-density of the atom, therefore, when the mass of an planet-constituting atom decays, the strength of the nuclear magnetic field will also decay. Thus, the existence of a law of inter-atomic bonding energy decay (of any of planet-occurring molecule). ...
A novel series of aminoethyl-O-chalcone by-products were developed using Claisen Schmidt condensation [40,41] and employed for AChE, AGEs, and free radical inhibitory potential in vitro. The most potent developed molecule was further tested in vivo using an STZ-induced rat model of dementia. ...
In addition to the inherent functionalization of natural cell membranes, several specific receptors and adhesion molecules on the membrane, such as C-C chemokine receptor 2, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1, can guide macrophage membrane-coated nanostructures into...
1 ChapterOutline •MatterandEnergy物質與能量•Chemistry–AMolecularViewofMatter•StatesofMatter•ChemicalandPhysicalProperties化學與物理性質•ChemicalandPhysicalChanges化學與物理變化•Mixtures,Substances,Compounds,andElements•MeasurementsinChemistry•UnitsofMeasurement•UseofNumbers•TheUnitFactorMethod(...
Our framework harnesses this power by using metabolic enzymes as transducers to allow us to “plug in” a given enzyme into our characterized biosensor modules to detect a ligand with no known corresponding TF (Fig. 1a). Specifically, the metabolic enzyme converts the undetectable molecule into ...
To obtain insight into the origins of the structural signatures of the first coordination shell, calculated EXAFS spectra of M-N4, M-N3-O, M-N2-O2, M-N-O3, M-O4, and M-N4-O2 (O2molecule adsorbed atop the metal center) configurations were employed for comparison with the experimental re...