Prof. Gonçalo Bernardes then introduced RNA degraders. As one of the central molecules for life, RNA was connected to various processes involved in diseases. Targeting RNA emerged as a significant endeavor in
Thus, we set out to develop a chemical method for the attachment of an additional (checkpoint inhibitory) protein to a BiTE core (Fig.1c). The method developed allowed for the introduction of small-molecule functionality to these three-protein constructs (in the form of a biotin molecule to ...
Here (O2)tis the mass (kg) of O2produced over a given timet(yr),Qizis the mass (g) of the isotope,Eais the average energy (eV) released from the decay of one atom;G(O2) is the radiation chemical yield of molecules per 100 eV of the radiation energy;MO2is the O2molecular mass...
When bridged oxygen atoms are periodically attached with the furazan rings, it can incredibly improve both the thermal stabilities and densities of the molecules [70]. Over the last couple of years, furazanyl ether compounds have been studying extensively due to their promising properties and ...
In the given reaction, we have starting molecules such as methane, Ethyne, and buta-1,3-diene that initially undergo a Diels-alder reaction. That...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your toug...
SsuD catalyzes C–S bond cleavage of C2-C10 alkyl-substituted sulfonates, in addition to alkyl chains with bulkier chemical groups and larger buffer molecules (26), whereas MsuD is reportedly most active with a C1 sulfonate (17). To date, no known alkanesulfonate monooxygenase structure has ...
ABSTRACT: Tertiary nitroalkanes, as well as their reduced products, α-tertiary amines, play an essential role in drug discovery as either key synthetic precursors or final motifs in targeted molecules. Existing methods to prepare tertiary nitro compounds generally rely on polar-bond disconnections, ...
The particles present in a solution – ions, molecules or colloids – are influenced by forces which cause them to migrate (diffuse) from areas of high concentration to areas of low concentration. The diffusion process continues until the whole solution is homogeneous, with the same conc...
Bin Liu for thesynthesis of organic molecules and nanomaterialsfor biomedical applications and Doug Stephan, forthe discovery of frustrated Lewis pairs and their role in catalysis. Given the Centenary’s success in picking work rewarded by the chemistry Nobel committee perhaps we’ll see one of ...
In the era of ecology and careful care for the environment, it becomes important to use renewable raw materials of plant origin, which are often more easil