X-RAY studies of the fibrous proteins indicate that they fall almost exclusively into one or other of two main configurational groups, the keratin-myosin group and the collagen group. The interpretation of the structure and properties of the former group is now well advanced and has frequently ...
The molecular conformation of the collagen triple helix confers strict amino acid sequence constraints, requiring a (Gly-X-Y)(n) repeating pattern and a high content of imino acids. The increasing family of collagens and proteins with collagenous domains shows the collagen triple helix to be a ...
Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans 1989, Gene Show abstract Basement Membrane Proteins: Molecular Structure and Function 1988, Advances in Protein Chemistry Show abstract Structure of the elastin gene and alternative splicing of elastin mRNA: Implications...
Inflammation is well known to lead to fibrosis. To test whether HSF1 affects fibrosis in the AOM-DSS model, we examined collagen deposition at day 52 by Masson trichrome and Sirius red staining. Both stains revealed increased collagen-rich fibrotic regions in WT colons compared to colons fromHsf...
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins,...
Integrins bind to collagen I via an inserted A domain (I domain) contained within the α subunit of the integrin. The crystal structure of the integrin α2 I domain when interacting with a triple-helical GFOGER motif has been resolved [10]. This shows that the carboxylate side chain on ...
The Best Quality of Collagen INTRODUCTIONCollagen is the most abundant and ubiquitous protein in animal origin, which comprising approximately 30% of total protein.Boom Hydrolysed collagen is produced by scientific processing of Gelatin, which is also called collagen peptide.Its relatively molecular weig...
Analysis of the primary structure of collagen for the origins of molecular packing The amino acid sequence in the triplet region of the 伪1 chain of collagen was analyzed for complementary relationships that would explain the stagger of multiples of 670 between the rod-like molecules in the fibril...
Lysyl hydroxylases catalyze hydroxylation of collagen lysines, and sustain essential roles in extracellular matrix (ECM) maturation and remodeling. Malfunctions in these enzymes cause severe connective tissue disorders. Human lysyl hydroxylase 3 (LH3/PLO
FOXA1 overexpression decreased fasting blood glucose and 24 h urinary protein concentration in mice, inhibited the accumulation of mesangial matrix and the proliferation of glomerular basement membrane, and ultimately reduced collagen deposition and interstitial fibrosis in mice kidneys [48]. ...