The helical structure of collagen has been extensively studied but in addition to its helical character, its molecular packing arrangement (in its aggregated or fibrillar form) and the presence of specific amino acid sequences govern collagen's in vivo functions. Collagen's molecular packing ...
2.We reviewed the molecular constitution,distribution,physiological functions,biochemistry and pathology of corneal collagen.本文简要概括了角膜胶原的分子结构、分布、生理生化和病理改变等方面的研究。 延伸阅读 分子结构分子结构molecularstructure原子在分子中的成键情形与空间排列。分子结构对物质的物理与化学性质有决定...
Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation. Our understanding of LH3 functions is currently hampered by lack of molecular structure information. Here, we present high resolution crystal ...
L. Influenza virus neuraminidase structure and functions. Front. Microbiol. 10, 39 (2019). Article PubMed PubMed Central Google Scholar Bartfeld, S. Modeling infectious diseases and host–microbe interactions in gastrointestinal organoids. Dev. Biol. 420, 262–270 (2016). Article CAS PubMed ...
of toxic protein aggregates and impairment of organelles, thus facilitating maintenance of organelle integrity and cellular homeostasis [20]. The specific regulatory functions of autophagy in hepatic homeostasis have been increasingly explored in recent years. Dysregulation of the autophagic process is ...
Many of these genes have various functions in cells (Supplementary data 2 and 2b), but a clear majority play important roles in the stress system (neuroendocrine immune complex) that regulates development, aging, circulatory, digestive, and other organismal systems. Functionally, these proteins are ...
The increasing family of collagens and proteins with collagenous domains shows the collagen triple helix to be a basic motif adaptable to a range of proteins and functions. Its rodlike domain has the potential for various modes of self-association and the capacity to bind receptors, other ...
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoc
The RBD comprises a core structure, which serves as a scaffold, and a receptor-binding motif (RBM), which mediates direct contact with ACE2 (ref.8). Because of its critical function, the RBM contains antigenic sites for eliciting potent neutralizing antibodies8. Recently, several highly potent...
The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 1985, 5, 683–692. [Google Scholar] [CrossRef] Wisse, E.; Knook, D.L. Kupffer Cells and Other Liver Sinusoidal Cells. In Proceedings of the...