The Molecular Mechanism by Which Insulin Activates Glycogen Synthase in Mammalian Skeletal Muscle 来自 Springer 喜欢 0 阅读量: 32 作者:P Cohen,PJ Parker,JR Woodgett 出版社: Springer US 摘要: One of the important metabolic effects of insulin is its ability to stimulate the synthesis of glycogen ...
The molecular mechanism by which omega-3 fatty acids regulate blood pressure is not fully understood, but it is thought to involve the inhibition of the production of inflammatory cytokines, which can cause the constriction of blood vessels and increase blood pressure106. Omega-3 fatty acids have...
In order to understand the molecular mechanism by which TIRR modulates 53BP1 function in response to DNA damage, we determined the crystal structure of TIRR and 53BP1 TTD complex at 2.0 Å resolution by X-ray diffraction (Fig. 1a). TIRR contains six α-helices and six β-strands, and...
The molecular mechanism of R414H, which lies at the extracellular C terminus of M4 (Fig. 1), remains elusive. Proposed Mechanism of Hyperekplexia by Gain-of-function GLRA1 Mutants Synaptic inhibition in adult spinal motor neurons is mediated exclusively by glycine (40, 41) or by a ...
We demonstrate that in contrast to previous findings by using simple synthetic promoters or activators, the natural IFN-β enhanceosome activates transcription by causing a dramatic increase of the rate by which preinitiation complexes assemble at the promoter. This effect totally depends on the recrui...
The molecular docking information pertaining to the components with strong binding power and the candidate targets is provided in Supplementary Table S5 (available in www.besjournal.com). The mechanism by which ginseng treatment ameliorates hypoxia can be explained more profoundly, as follows. Ki is ...
The molecular mechanism is based on the binding of a methyl/acetyl group to a DNA molecule, which may affect the transcriptional activity of the underlying gene without changing the genetic code. The percentage of methylation inherited from the father through sperm varies markedly across taxa and ...
The molecular mechanism by which plant cells relay calcium signals in response to hypoxia remains elusive. This study reveals that hypoxia stress rapidly stimulates Arabidopsis CPK12 and promotes its relocation from the cytoplasm to the nucleus, where it interacts with and phosphorylates ERF-VII tranio...
Molecular mechanism of prestin electromotive signal amplification. Cell 184, 4669–4679 (2021). Article CAS PubMed Google Scholar Butan, C. et al. Single particle cryo-EM structure of the outer hair cell motor protein prestin. Preprint at bioRxiv https://doi.org/10.1101/2021.08.03.454998 (...
et al. The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen. Biochem. Biophys. Res. Commun. 36, 891–897 (1969). Article CAS PubMed Google Scholar Geary, L. E. & Meister, A. On the mechanism of glutamine-dependent ...