doi:10.1016/j.psyneuen.2015.07.408Rachel D. MoloneyTimothy G. DinanJohn F. CryanPsychoneuroendocrinology
In turn, the brain influences the intestinal microbial composition through neuroendocrine signals, within the so-called gut microbiota-brain axis. The balance of this bidirectional crosstalk is important to ensure neurogenesis, preserve the integrity of the blood-brain barrier and avoid neuroinflammation....
3. Microbiota-Gut-Brain (MGB) axis 4. Comorbidity with Type II diabetes 5. Predictive and diagnostic potential of gut microbiota 6. Therapeutic potential of gut microbiota 7. Limitations and future directions 8. Conclusion Funding CRediT authorship contribution statement Institutional Review Board Statem...
the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal
On the other hand, multi- ple factors in gut, including inflammatory mediators, gut microbiota profile, and stress hormones, affect the function of the central nervous system [3, 5]. The dys- function of the gut-brain axis has been involved in several neurological diseases, such as multiple...
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats Shaoyang Liu Shuting Zhuang Haoru Duan Diabetology & Metabolic Syndrome(2025) ...
Gut microbiota The collective microorganisms (bacteria, archaea, fungi and viruses) that reside in the gastrointestinal tract. Probiotics Live microorganisms with purported health benefits when consumed, mainly as a result of improving or restoring the gut microbiota. Xenobiotics Chemical substances found ...
(FFAR2/GPR43) and reshape gut microbiota, leading to increased expression of inflammation suppressors and prevention of intestinal carcinogenesis [169]. In contrast, GPR43 deficiency results in enhanced cAMP-PKA-CREB signaling and HDAC expression, thereby promoting colon carcinogenesis by inhibiting the...
In 2015, the gut microbiota was shown to participate in the biosynthesis of serotonin (5-HT)9, thus, the “gut–brain axis” hypothesis was for the first time demonstrated with clear chemical evidence. However, this study showed that spore-forming bacteria from the mice or human microbiota ...
Bile acids Cardiovascular disease Microbiota-gut-heart axis Therapeutic strategy 1. Introduction Cardiovascular disease (CVD) refers a group of disorders of the heart and blood vessels. These disorders include coronary heart disease, cerebrovascular disease, rheumatic heart disease, and other conditions. ...