Insulin, insulin-like growth factor 1 (IGF1), and insulin-like growth factor 2 (IGF2) activate a family of receptor tyrosine kinases [4]. However, the other structurally similar peptides, which are related to relaxin, are functionally distinct and activate G-protein-coupled receptors [5, 6...
Feng YM,et al.Studies on the mechanisms of insulin action Ⅵ.The interaction of insulin fragnents with insulin receptor.Insulin:Chemistry,Structure and Function of Insulin and Related Hormones. 1980Studies on the mechanisms of insulin action Ⅵ.The interaction of insulin fragnents with insulin ...
Insulin as an amplifier of gonadotropin action on steroid production: mechanisms and sites of action in goldfish prematurational full-grown ovarian follicles. The present study examines the effects of mammalian insulin and insulin-like growth factor-I (IGF-I) on steroid production by goldfish vitello...
The mechanisms of insulin action Author links open overlay panelK.W. TaylorShow more Add to Mendeley Share Cite https://doi.org/10.1016/0014-5793(87)80780-9Get rights and content Under an Elsevier user license open archivePrevious article in issue Next article in issue...
It provides a comprehensive view of the nature and mechanisms of action of these second messengers. Insulin has been one of the best studied mammalian proteins. After 1955, insulin became the first mammalian protein to be chemically synthesized. The molecular mechanisms underlying the multiple ...
(i) Insulin has an immediate physical action on the cell/extracellular interface, altering the redox potential gradient (electron conductance) across the plasma membrane. (ii) Conversely, the formation of an insulin-membrane complex depends, among other factors, on the prevailing trans-membrane redox...
(redirected fromMechanisms of action) Medical mech´an`ism of ac´tion n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding ...
Molecular mechanisms of insulin action in normal and insulin-resistant states (see comments) Such a process could contribute to the defective IRS-1 tyrosine phosphorylation in insulin-resistant animals. We found that brief exposure of 3T3-L1 ... MBY Le - 《Experimental & Clinical Endocrinology &...
Petersen, M. C. & Shulman, G. I. Mechanisms of insulin action and insulin resistance.Physiol. Rev.98, 2133–2223 (2018). ArticleCASPubMedPubMed CentralGoogle Scholar Semple, R. K., Savage, D. B., Cochran, E. K., Gorden, P. & O’Rahilly, S. Genetic syndromes of severe insulin ...
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