Unlike all other vertebrates studied, we discovered that the MC1R gene in P. sicula consists of two exones. The first codes for the entire protein (314 aa), and the second includes the stop codon and 3' UTR (see Additional file 1, the sequences were deposited in Genbank under the acc...
Candidate genes for additional cave phenotypes. Lastly, we sought to briefly investigate other distinctive traits for cavefish, including reduced pigmentation5,6. First, we found that one of the most famous pigmentation genes, mc1r, known to be mutated in Pacho´n cavefish5 (the population ...
Unlike all other vertebrates studied, we discovered that the MC1R gene inP. siculaconsists of two exones. The first codes for the entire protein (314 aa), and the second includes the stop codon and 3' UTR (see Additional file1, the sequences were deposited in Genbank under the accession...
DT+and VT+cells expressed key ER genes and exhibited substantially reduced genomic 5mC levels (Extended Data Fig.4q,r). Of note, hPGCLC-derived cells could be frozen and stored and were re-expandable after thawing (Extended Data Fig.4s). They also propagated and differentiated into DT+or ...
For example, ZDHHC6-mediated palmitoylation of AEG-1 enhances proteasomal degradation of AEG-1, suppressing HCC tumor growth75. ZDHHC7-mediated SCRIB palmitoylation enhances tumor suppressive activity of SCRIB76. Melanocortin 1 receptor (MC1R) palmitoylation by ZDHHC13 is essential for the activation ...
MC1R is a member of the same gene superfamily as a human gene called CCR5, which is pivotal in letting HIV enter a cell. CCR5 codes for a protein that sits in the membrane of a cell and can be used as a doorway by a variety of infecting viruses. “So perhaps the selective pressure...
The "amber" gene hypothesis was not confirmed; nothing was found in the MC1R gene in British cats. One opinion is that "Golden Chinchilla" without the "milky-white" chest is really a shaded colour (not a tipped colour) where black pigment at the hair tips is maximally transformed into ...
For genomic alterations, recurrent mutations in breast cancer, such asPIK3CA,TP53, andGATA3, were found in HER2-low breast cancers, and the downstream effects of copy number alterations (CNAs) can also be seen at the RNA and protein levels (Supplementary Fig.S2). In addition, at the ...
ATP5MC1, ATP synthase subunit C1; CAPN2, calpain 2; CASP6, caspase 6; CAS9, caspase 9; CFAP74, cilia and flagella associated protein 74; CRYAB, CRYBA1, CRYGD, crystallins; CX3CR1, chemokine receptor; DDX60L,DExD/H-box 60 like; DNAJC28, DnaJ heat shock protein; F2RL1, coagulatio...