Methods Clinical isolates of Escherichia coli and Klebsiella pneumoniae were collected from patients with bloodstream infections at 28 hospitals in China, then screened for colistin resistance by broth microdilution and for the presence of the mcr-1 gene by PCR amplification. We subjected mcr-1-positiv...
Colonization of chicken gut by pathogenicEscherichia coliharboring mobile colistin resistance (mcr-1) gene is a huge public and animal health risk. This study was undertaken to evaluate colistin (COL) resistance transfer potentials and pathogenicity ofmcr-1-positiveE.coliisolates from chickens in ...
including strains withepidemic4potential, according to new research published in The Lancet Infectious Diseases. The mcr-1 gene was found on plasmids, mobileDNA5that can
MCR-1 介导多黏菌素耐药性的分子机制研究进展 The emergence of the polymyxin resistance gene mcr-1 has brought new challenges to the treatment of clinical infections. mcr)1 has been reported from 61 di... 陈勇,李亚鑫,王亚瑄,... - 《Biotechnology Bulletin》 被引量: 0发表: 2023年 加载更多来源...
研究成果以“The global distribution and spread of the mobilized colistin resistance genemcr-1”为题,于2018年3月23日在《Nature Communications》上在线发表。北京大学人民医院王辉教授和伦敦大学学院Francois Balloux教授为该文的共同通讯作者,博士生王若冰、博士后Lucy van Dorp和博士生Liam P. Shaw为共同第一作者...
RPA-LFD quantitative analysis showed that the concentration of mcr-1 gene in positive samples was between 4.5×102~8.6×104 copies/µL. Conclition: The RPA-LFD detection method of the bacterial colistin resistance gene mcr-1 established in this study had strong specificity, high sensitivity, ...
on MALDI-TOF MS implied the existence of horizontal transmission of mcr -1 gene in the intestinal microbiota.Key words: mcr -1 gene; matrix assisted laser desorption/ionization-time of fl ight mass spectrometry; dendrogram ; pig; gut fl ora Copyright ©博看网. All Rights Reserved.
The mcr-1 gene outcome product MCR-1 is a PEA lipid transferase which may cause polymyxin resistance, and zinc ions are essential for functioning of MCR-1, though biological linking sites of zinc are still not well identified (Son et al., 2019). A two-step mechanism of MCR-1 action ...
目前发现多黏菌素耐药机制 •two-componentsystems[pmrAB[6]andphoPQ[7])andtheregulatormgrB •theplasmid-mobilizedcolistinresistance(MCR-1)•SincethefirstdiscoveryofMCR-1fromSouthernChina,inthelateof2015,thenewcolistinresistancegenehasspreadto5of7continents •nolessthansixspeciesofEnterobacteriaceae(E....
题目:Highly Sensitive and Specific Detection of Mobilized Colistin Resistance Gene mcr-1 by CRISPR-Based Platform 期刊:Microbiol Spectr 影响因子:9.043 研究背景 质粒介导的可移动粘杆菌素耐药酶(mobilized colistin resistance,mcr-1)基因可导致耐药株的快速传播,给人类感染的治疗带来极大威胁。本研究将RPA与CRISPR...