Resistance to last resort drug (colistin) and the isolation of mcr-1 indicate further urgency in infection management. Therefore, extensive surveillance, formulation and implementation of effective policies, augmentation of diagnostic facilities and incorporation of antibiotic stewardship programs can be some...
A newgene1(mcr-1) that enables bacteria to be highlyresistant2to polymyxins, the last line ofantibiotic3defence we have left, is widespread in Enterobacteriaceae [1] taken from pigs and patients in south China, including strains withepidemic4potential, according to new research published in The ...
Plasmid-mediated colistin resistance: an additional antibiotic resistance menace. Clinical Microbiol Infection , 2016 , 22: 398 -400 CrossRef PubMed Google Scholar [2] Falagas M E, Rafailidis P I, Matthaiou D K. Resistance to polymyxins: Mechanisms, frequency and treatment options. Drug ...
The plasmid-bornemcr-1gene confers resistance to the antibiotic colistin. Here, MacNair et al. show thatmcr-1positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo by combining colistin with other antibiotics....
A plasmid carrying the colistin resistance gene mcr-1 was isolated from a pig slurry sample in Estonia. The gene was present on a 33,311-bp plasmid of the IncX4 group. mcr-1 is the only antibiotic resistance gene on the plasmid, with the other genes mainly coding for proteins involved...
Mcr1 was confined to China at the time of the first report, but as of February 2017, the gene had been detected in more than 30 countries on five continents, posing a serious escalation of the current antibiotic resistance crisis [7]. More recently, genetic variants of mcr1 have been ...
Chineseresearchersdiscovered the plasmid-mediated colistin resistance genemcr-1, indicating that this last defense line is at risk of being breached. However, the effect of bactericidal concentration and sub-inhibitory concentration of colistin on the transmission ofmcr-1-positiveplasmid is still unknown...
K. et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10, 597–602 (2010). Article CAS Google Scholar Munoz-Price, L. S. et al. Clinical epidemiology of the global expansion ...
2. This finding indicated the dissemination of this gene between both sources. Moreover, this finding confirmed the role of wild birds in antibiotic resistance as they consider a potential spreader of antibiotic resistance through the ability to migrate long distances in short periods of time and ...
The plasmid-bornemcr-1gene confers resistance to the antibiotic colistin. Here, MacNair et al. show thatmcr-1positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo by combining colistin with other antibiotics. 展开...