In exploring the chromatin compartmental diversity across cell types and developmental stages, we found that cell types showing the LE conformation are associated with a stronger compartment strength: compartmentalization strength scores are inversely correlated with the ratio of short- to long-range intera...
The induction did not occur intwa1protoplasts and was enhanced in TWA1(oe) cells (Fig.4e). A thermal response shift to lower and higher temperatures occurred in protoplasts fromAlTWA1(oe1) andSaTWA1(oe1) plants expressing the lyrate and mustard orthologue in thetwa1-2genotype compared with ...
Here we sought to define the host immune response, a.k.a, the “cytokine storm” that has been implicated in fatal COVID-19 using an AI-based approach. Method Over 45,000 transcriptomic datasets of viral pandemics were analyzed to extract a 166-gene signature using ACE2 as a ‘seed’ ...
but did not affect delay fear conditioning (DFC), a form of hippocampus-independent learning (Fig.3d). Because viral injections are known to cause inflammatory responses of astrocytes and microglia (as confirmed in our post-mortem analysis; Extended Data Fig.4b), we also determined the contributi...
To understand the variation in rumen fermentation function of newly received cattle during receiving period, ruminal pH, NH3-N, microbial crude protein (MCP), and VFA were measured. During the receiving period, the ruminal pH was lowest and the MCP concentration was highest at day 16 post-trans...
Assembly statistics were calculated using the TrinityStats.pl script and the completeness of the assembly was assessed with BUSCO (Benchmarking Universal Single-Copy Orthologs) v. 1.22 [78] against the "eukaryota_odb9" reference set. TransRate v. 1.0.1 [79] was used to evaluate the assembly ...
Proton pump inhibitors (PPIs) are commonly used to lessen symptoms in patients with gastroesophageal reflux disease (GERD). However, the effects of PPI therapy on the gastrointestinal microbiota in GERD patients remain unclear. We examined the association between the PPI usage and the microbiota prese...
Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, we combine a chemogenetic mouse model (HyPer-DAO mice) and ...
heat-triggered increases in hydrogen peroxide53,54and nitrogen oxide55activate HSFA1s and allow for redox signal integration into the HSR. TWA1 possibly provides another node of signal integration. Plants frequently experience combined stress with the challenge to integrate conflicting single stress respon...
After washing off the hydrogen peroxide, 10% goat serum was used to block it for half an hour. The primary antibody was incu- bated at 37 °C for 1 h, and the secondary antibody was incubated for 15 min (primary and secondary antibod- ies information were shown in ...